Imperial College London
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ProfessorJ SimonKroll

Faculty of Medicine, Department of Infectious Disease

Emeritus Professor,Paediatrics&Molecular Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3695s.kroll

 
 
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Assistant

 

Dr Robert Boyle +44 (0)20 7594 3990

 
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Location

 

245Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wopereis:2018:10.1016/j.jaci.2017.05.054,
author = {Wopereis, H and Sim, K and Shaw, A and Warner, JO and Knol, J and Kroll, J},
doi = {10.1016/j.jaci.2017.05.054},
journal = {Journal of Allergy and Clinical Immunology},
pages = {1334--1342.e5},
title = {Intestinal microbiota in infants at high risk for allergy: effects of prebiotics and role in eczema development},
url = {http://dx.doi.org/10.1016/j.jaci.2017.05.054},
volume = {141},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: The development of gut microbiota in infancy is important in the maturation of the immune system. Deviations in colonization patterns have been associated with allergic manifestations (e.g. eczema), but exact microbiome dysfunctions underlying allergies remain unclear. We studied the gut microbiota of 138 infants at increased risk of developing allergy, participating in a clinical trial investigating the effectiveness of a partially hydrolyzed protein formula supplemented with non-digestible oligosaccharides (pHF-OS) on the prevention of eczema. Objective: The effects of the interventions and breastfeeding on fecal microbiota were investigated. Additionally, we aimed to identify microbial patterns associated with the onset of eczema. Methods: Bacterial taxonomic compositions in the first 26 weeks of life were analyzed using 16S rRNA-gene sequencing. Additionally, fecal pH and microbial metabolites were measured. Results: Fecal microbial composition, metabolites and pH of infants receiving pHF-OS was closer to breastfed infants than to infants receiving standard cow’s milk formula. Infants developing eczema by 18 months showed temporal differences that were marked by decreased relative abundances of Parabacteroides and Enterobacteriaceae at 4 weeks, and decreased relative abundances of lactate-utilizing bacteria producing butyrate at 26 weeks, namely Eubacterium and Anaerostipes spp., supported by increased lact ate and decreased butyrate levels. Conclusions: We showed that a pHF with specific prebiotics modulated the gut microbiota closer to that of breastfed infants. Additionally, we identified a potential link between the microbial activity and onset of eczema, which may reflect a suboptimal implementation of gut microbiota at specific developmental stages in infants at high-risk for allergy.
AU  - Wopereis,H
AU  - Sim,K
AU  - Shaw,A
AU  - Warner,JO
AU  - Knol,J
AU  - Kroll,J
DO  - 10.1016/j.jaci.2017.05.054
EP  - 1342
PY  - 2018///
SN  - 1097-6825
SP  - 1334
TI  - Intestinal microbiota in infants at high risk for allergy: effects of prebiotics and role in eczema development
T2  - Journal of Allergy and Clinical Immunology
UR  - http://dx.doi.org/10.1016/j.jaci.2017.05.054
UR  - https://www.sciencedirect.com/science/article/pii/S009167491731343X?via%3Dihub
UR  - http://hdl.handle.net/10044/1/48443
VL  - 141
ER  -
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