Dr Sylvain Ladame received his Ph.D. in Chemistry of biomolecules in 2001 from the University of Toulouse, France. He then worked for five years in the group of Pr Shankar Balasubramanian at the Chemistry Department of the University of Cambridge (U.K.) where he developed an interest in the molecular recognition of nucleic acids. In 2006, he joined the CNRS and the Institut de Science et d’Ingénierie Supramoléculaires (ISIS) at the University of Strasbourg, France, where he created the junior research laboratory of Chemistry of Biomolecules. In July 2010, he has been appointed Lecturer in Biosensor Development at the Department of Bioengineering of Imperial College.
Dr Ladame has been working in the field of nucleic acid ligands and probes for almost ten years and has published over 30 papers in this field. His current interests deal with the engineering of small molecules and proteins for sensing and targeting nucleic acid structures in vivo. Dr Ladame's group aims to develop original chemical and biochemical tools to explore key biological processess (e.g. DNA transcription, DNA damage repair mechanisms), focusing on the identification of new therapeutic targets and of disease-related biomarkers.
Applications from prospective postgraduate students and highly motivated researchers are welcome at any time and can be submitted by email.
To access the Ladame group website, click here.
Keywords: Nucleic Acids; Biosensors; Transcription; DNA damage; Fluorosensors; G-quadruplexes
Sylvain’s research publications can be found at the tab above, or on Google Scholar
Koripelly G, Meguellati K, Ladame S, 2010, Dual Sensing of Hairpin and Quadruplex DNA Structures Using Multicolored Peptide Nucleic Acid Fluorescent Probes, Bioconjugate Chemistry, Vol:21, ISSN:1043-1802, Pages:2103-2109
et al., 2008, First evidence of a functional ineraction between DNA quadruplexes and poly(ADP-ribose) polymerase-1, ACS Chemical Biology, Vol:3, ISSN:1554-8929, Pages:214-219
et al., 2008, Combining G-Quadruplex Targeting Motifs on a Single Peptide Nucleic Acid Scaffold: A Hybrid (3+1) PNA-DNA Bimolecular Quadruplex, Chemistry - A European Journal, Vol:14, ISSN:0947-6539, Pages:8682-8689
Meguellati K, Koripelly G, Ladame S, 2010, DNA-Templated Synthesis of Trimethine Cyanine Dyes: A Versatile Fluorogenic Reaction for Sensing G-Quadruplex Formation, Angewandte Chemie - International Edition, Vol:49, ISSN:1433-7851, Pages:2738-2742