Imperial College London

DrSongLuan

Faculty of EngineeringDepartment of Electrical and Electronic Engineering

Research Associate
 
 
 
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Contact

 

s.luan Website CV

 
 
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Location

 

422Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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15 results found

Luan S, Williams I, Maslik M, Liu Y, De Carvalho F, Jackson A, Quiroga RQ, Constandinou TGet al., 2018, Compact standalone platform for neural recording with real-time spike sorting and data logging., J Neural Eng, Vol: 15

OBJECTIVE: Longitudinal observation of single unit neural activity from large numbers of cortical neurons in awake and mobile animals is often a vital step in studying neural network behaviour and towards the prospect of building effective brain-machine interfaces (BMIs). These recordings generate enormous amounts of data for transmission and storage, and typically require offline processing to tease out the behaviour of individual neurons. Our aim was to create a compact system capable of: (1) reducing the data bandwidth by circa 2 to 3 orders of magnitude (greatly improving battery lifetime and enabling low power wireless transmission in future versions); (2) producing real-time, low-latency, spike sorted data; and (3) long term untethered operation. APPROACH: We have developed a headstage that operates in two phases. In the short training phase a computer is attached and classic spike sorting is performed to generate templates. In the second phase the system is untethered and performs template matching to create an event driven spike output that is logged to a micro-SD card. To enable validation the system is capable of logging the high bandwidth raw neural signal data as well as the spike sorted data. MAIN RESULTS: The system can successfully record 32 channels of raw neural signal data and/or spike sorted events for well over 24 h at a time and is robust to power dropouts during battery changes as well as SD card replacement. A 24 h initial recording in a non-human primate M1 showed consistent spike shapes with the expected changes in neural activity during awake behaviour and sleep cycles. SIGNIFICANCE: The presented platform allows neural activity to be unobtrusively monitored and processed in real-time in freely behaving untethered animals-revealing insights that are not attainable through scheduled recording sessions. This system achieves the lowest power per channel to date and provides a robust, low-latency, low-bandwidth and verifiable outp

JOURNAL ARTICLE

Williams I, Rapeaux A, Luan S, Constandinou TGet al., 2018, Waveform Generator

PATENT

Liu Y, Luan S, Williams I, Rapeaux A, Constandinou TGet al., 2017, A 64-Channel Versatile Neural Recording SoC With Activity-Dependent Data Throughput, IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, Vol: 11, Pages: 1344-1355, ISSN: 1932-4545

JOURNAL ARTICLE

Luan S, Liu Y, Williams I, Constandinou TGet al., 2016, An Event-Driven SoC for Neural Recording, 12th IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 404-407, ISSN: 2163-4025

CONFERENCE PAPER

Luan S, Williams I, de Carvalho F, Jackson A, Quian Quiroga R, Constandinou TGet al., 2016, Next Generation Neural Interfaces for low-power multichannel spike sorting, FENS Forum of Neuroscience, Publisher: FENS

CONFERENCE PAPER

Williams I, Rapeaux A, Liu Y, Luan S, Constandinou TGet al., 2016, A 32-Ch. Bidirectional Neural/EMG Interface with on-Chip Spike Detection for Sensorimotor Feedback, 12th IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 528-531, ISSN: 2163-4025

CONFERENCE PAPER

Williams I, Luan S, Jackson A, Constandinou TGet al., 2015, A Scalable 32 Channel Neural Recording and Real-time FPGA Based Spike Sorting System, 11th IEEE Annual Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 188-191, ISSN: 2163-4025

CONFERENCE PAPER

Williams I, Luan S, Jackson A, Constandinou TGet al., 2015, Live Demonstration: A Scalable 32-Channel Neural Recording and Real-time FPGA Based Spike Sorting System, 11th IEEE Annual Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 187-187, ISSN: 2163-4025

CONFERENCE PAPER

Luan S, Constandinou TG, 2014, A charge-metering method for voltage-mode neural stimulation, JOURNAL OF NEUROSCIENCE METHODS, Vol: 224, Pages: 39-47, ISSN: 0165-0270

JOURNAL ARTICLE

Luan S, Williams I, Nikolic K, Constandinou TGet al., 2014, Neuromodulation: present and emerging methods., Front Neuroeng, Vol: 7, ISSN: 1662-6443

Neuromodulation has wide ranging potential applications in replacing impaired neural function (prosthetics), as a novel form of medical treatment (therapy), and as a tool for investigating neurons and neural function (research). Voltage and current controlled electrical neural stimulation (ENS) are methods that have already been widely applied in both neuroscience and clinical practice for neuroprosthetics. However, there are numerous alternative methods of stimulating or inhibiting neurons. This paper reviews the state-of-the-art in ENS as well as alternative neuromodulation techniques-presenting the operational concepts, technical implementation and limitations-in order to inform system design choices.

JOURNAL ARTICLE

Leene LB, Luan S, Constandinou TG, 2013, A 890fJ/bit UWB transmitter for SOC integration in high bit-rate transcutaneous bio-implants, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 2271-2274, ISSN: 0271-4302

CONFERENCE PAPER

Guilvard A, Eftekhar A, Luan S, Toumazou C, Constandinou TGet al., 2012, A Fully-Programmable Neural Interface for Multi-Polar, Multi-Channel Stimulation Strategies, IEEE International Symposium on Circuits and Systems, Publisher: IEEE, Pages: 2235-2238, ISSN: 0271-4302

CONFERENCE PAPER

Luan S, Constandinou TG, 2012, A Novel Charge-Metering Method for Voltage Mode Neural Stimulation, IEEE International Symposium on Circuits and Systems, Publisher: IEEE, Pages: 2239-2242, ISSN: 0271-4302

CONFERENCE PAPER

Mirza KB, Luan S, Eftekhar A, Constandinou TGet al., 2012, Towards a Fully-Integrated Solution for Capacitor-based Neural Stimulation, IEEE International Symposium on Circuits and Systems, Publisher: IEEE, Pages: 2243-2246, ISSN: 0271-4302

CONFERENCE PAPER

Luan S, Eftekhar A, Murphy OH, Constandinou TGet al., 2011, Towards an Inductively Coupled Power/Data Link for Bondpad-less Silicon Chips, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 2597-2600, ISSN: 0271-4302

CONFERENCE PAPER

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