Steven Marston is Professor of Cardiovascular Biochemistry and has been at the National Heart and Lung Institute division of Imperial College London and its predecessors since 1981.
He obtained a BSc in Biochemistry (1970) and DPhil (1973) at Oxford University, followed by postdoctoral research at the University of Pennsylvania (Prof. A Weber), University of Chicago (Prof EW Taylor) and in the Zoology department at Oxford University (Dr RT Tregear). From 1978 to 1981 her was a research scientist at ICI Pharmaceuticals (now part of Astra-Zenica)
His research career has been devoted to investigating the molecular mechanism of muscle contraction and its regulation by Ca2+ and phosphorylation. Muscle systems studied include insect flight muscle (basic mechanisms of force generation and mechano-chemical coupling), vascular smooth muscle (discovery and comprehensive investigation of the thin filament regulatory protein caldesmon), skeletal muscle (investigation of fundamental mechanisms of congenital myopathies due to actin and tropomyosin mutations) and cardiac muscle.
His recent research has concentrated on cardiomyopathies, both acquired heart failure and the genetic myopathies, hypertrophic cardiomyopathy and dilated cardiomyopathy.
His research group investigates mechanisms of regulation at the single filament level by in vitro motility assays and also in more organised systems including human heart muscle and transgenic mouse models of cardiomyopathies. This approach recognizes the fact that animal models alone are often inadequate representations of human disease whilst investigation on human tissue has practical limitations and the state of tissue examined may not be physiological. By applying a common range of experimental techniques to both animal and human heart resolution of these problems becomes more likely.
Professor Marston is a past member of:
- Editorial Board, Biochemical Journal
- Editorial Board International Journal of Biochemistry
- BHF Fellowship Committee member
- Clinical Research Committee, Royal Brompton Hospital
- Editorial Board, Calcium Binding Proteins
He is currently an Editor of Journal of Muscle Research and Cell motility, Chair of the Imperial /London Muscle Initiative and British rep on the Council of European Society for Muscle Research
He has organised conferences including:
- European Conference on Smooth Muscle, 1988
- London Muscle Symposium 1990, 1995, 2000, 2002, 2004
- Cardiac Muscle functional proteomics workshop, 2006
- Organisation of European Muscle Congress, September 2008
He currently holds a programme grant, three PhD fellowships and a project grant from the British Heart Foundation and is a partner in the EU FP7 "BIG Heart" consortium.
et al., Investigations into the sarcomeric protein and Ca2+-regulation abnormalities underlying hypertrophic cardiomyopathy in cats (felix catus), Frontiers in Physiology, ISSN:1664-042X
Marston S, 2017, Obscurin variants and inherited cardiomyopathies., Biophys Rev, ISSN:1867-2450
et al., 2016, Myopathy-inducing mutation H40Y in ACTA1 hampers actin filament structure and function, Biochimica Et Biophysica Acta-molecular Basis of Disease, Vol:1862, ISSN:0925-4439, Pages:1453-1458
Vikhorev P, Marston S, THE EFFECT OF DCM-ASSOCIATED MUTATIONS IN TITIN ON HUMAN CARDIAC MYOFIBRIL ELASTICITY AND CONTRACTILITY., 15th Alpbach Motors Workshop. Myosin & Muscles, and other Motors., Pages:115-115
Abou Al Saud S, 2016, Investigation of Phenotypic Rescue of Mybpc3 Deficient Mouse