Imperial College London

ProfessorStevenMarston

Faculty of MedicineNational Heart & Lung Institute

(Non-Clinical) Professor in Cardiovascular Biochemistry
 
 
 
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Contact

 

+44 (0)20 7594 2732s.marston Website

 
 
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Location

 

433ICTEM buildingHammersmith Campus

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Summary

 

Summary

Steven Marston is Professor of Cardiovascular Biochemistry and has been at the National Heart and Lung Institute division of Imperial College London and its predecessors since 1981.

He obtained a BSc in Biochemistry (1970) and DPhil (1973) at Oxford University, followed by postdoctoral research at the University of Pennsylvania (Prof. A Weber), University of Chicago (Prof EW Taylor) and in the Zoology department at Oxford University (Dr RT Tregear).   From 1978 to 1981 her was a research scientist at ICI Pharmaceuticals (now  part of Astra-Zenica)

His research career has been devoted to investigating the molecular mechanism of muscle contraction and its regulation by Ca2+ and phosphorylation.  Muscle systems studied include insect flight muscle (basic mechanisms of force generation and mechano-chemical coupling), vascular smooth muscle (discovery and comprehensive investigation of the thin filament regulatory protein caldesmon),  skeletal muscle (investigation of fundamental mechanisms of congenital myopathies due to actin and tropomyosin mutations) and cardiac muscle.
His recent research has concentrated on cardiomyopathies, both acquired heart failure and the genetic myopathies, hypertrophic cardiomyopathy and dilated cardiomyopathy.

His research group investigates mechanisms of regulation at the single filament level by in vitro motility assays and also in more organised systems including human heart muscle and transgenic mouse models of cardiomyopathies. This approach recognizes the fact that animal models alone are often inadequate representations of human disease whilst investigation on human tissue has practical limitations and the state of tissue examined may not be physiological. By applying a common range of experimental techniques to both animal and human heart resolution of these problems becomes more likely.

Professor Marston is a past member of:

  • Editorial Board, Biochemical Journal
  • Editorial Board International Journal of Biochemistry
  • BHF Fellowship Committee member
  • Clinical Research Committee,  Royal Brompton Hospital
  • Editorial Board, Calcium Binding Proteins

He is currently an Editor of Journal of Muscle Research and Cell motility, Chair of the Imperial /London Muscle Initiative and British rep on the Council of European Society for Muscle Research

He has organised conferences including:

  • European Conference on Smooth Muscle, 1988
  • London Muscle Symposium 1990, 1995, 2000, 2002, 2004
  • Cardiac Muscle functional proteomics workshop, 2006
  • Organisation of European Muscle Congress, September 2008

He currently holds a programme grant, three PhD fellowships and a project grant from  the British Heart Foundation and is a partner in the EU FP7 "BIG Heart" consortium.

Publications

Journals

Vikhorev, Smoktunowicz N, Munster A, et al., Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes., Scientific Reports, ISSN:2045-2322

Dos Remedios CG, Lal SP, Li A, et al., 2017, The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease., Biophys Rev, ISSN:1867-2450

Marston S, 2017, Obscurin variants and inherited cardiomyopathies., Biophys Rev, Vol:9, ISSN:1867-2450, Pages:239-243

Messer AE, Chan J, Daley A, et al., 2017, Investigations into the Sarcomeric Proteinand Ca2+-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats(Felix catus), Frontiers in Physiology, Vol:8, ISSN:1664-042X

Conference

Vikhorev P, Marston S, THE EFFECT OF DCM-ASSOCIATED MUTATIONS IN TITIN ON HUMAN CARDIAC MYOFIBRIL ELASTICITY AND CONTRACTILITY., 15th Alpbach Motors Workshop. Myosin & Muscles, and other Motors., Pages:115-115

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