Imperial College London

ProfessorSteveMarston

Faculty of MedicineNational Heart & Lung Institute

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 2732s.marston Website

 
 
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Location

 

433ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Marston:2019:10.1007/s10974-019-09526-w,
author = {Marston, S},
doi = {10.1007/s10974-019-09526-w},
journal = {Journal of Muscle Research and Cell Motility},
pages = {69--76},
title = {Small molecule studies: the fourth wave of muscle research},
url = {http://dx.doi.org/10.1007/s10974-019-09526-w},
volume = {40},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The study of muscle and contractility is an unusual scientific endeavour since it has from the start been focussed on one problem-What makes muscle work?-and yet has needed a vast range of different approaches and techniques to study it. Its uniqueness lies in the fundamental fascination of a large scale molecular machine that converts chemical energy into mechanical energy at ambient temperature and with high efficiency that is also controlled by an exquisitely intricate yet utterly reliable regulatory system and is an essential component of animal life. The investigation of muscle is as innovative as any other field of research. As soon as one approach appears to be played out another comes along. It is instructive to consider this as a series of waves of novel and heightened activity starting in the 1950s. The thesis of this article is that we are approaching the fourth wave with the recent rise of interest in small molecules as research tools and possible therapies for muscle diseases.
AU - Marston,S
DO - 10.1007/s10974-019-09526-w
EP - 76
PY - 2019///
SN - 0142-4319
SP - 69
TI - Small molecule studies: the fourth wave of muscle research
T2 - Journal of Muscle Research and Cell Motility
UR - http://dx.doi.org/10.1007/s10974-019-09526-w
UR - https://www.ncbi.nlm.nih.gov/pubmed/31228047
UR - http://hdl.handle.net/10044/1/71043
VL - 40
ER -