Imperial College London
Alternate

Spyros Masouros

Faculty of Engineering, Department of Bioengineering

Reader in Injury Biomechanics
 
 
 
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Contact

 

+44 (0)20 7594 2645s.masouros04 Website

 
 
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Location

 

U516ASir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Newell:2019:10.1016/j.spinee.2019.07.012,
author = {Newell, N and Carpanen, D and Grigoriadis, G and Little, JP and Masouros, S},
doi = {10.1016/j.spinee.2019.07.012},
journal = {Spine Journal},
pages = {2013--2024},
title = {Material properties of human lumbar intervertebral discs across strain rates},
url = {http://dx.doi.org/10.1016/j.spinee.2019.07.012},
volume = {19},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background context:The use of finite-element (FE) methods to study the biomechanics of the intervertebral disc (IVD) has increased over recent decades due to their ability to quantify internal stresses and strains throughout the tissue. Their accuracy is dependent upon realistic, strain-rate dependent material properties, which are challenging to acquire. Purpose:The aim of this study was to use the inverse FE technique to characterize the material properties of human lumbar IVDs across strain rates.Study Design:A human cadaveric experimental study coupled with an inverse finite element study.Methods:To predict the structural response of the IVD accurately, the material response of the constituent structures was required. Therefore, compressive experiments were conducted on 16 lumbar IVDs (39 ± 19 years) to obtain the structural response. An FE model of each of these experiments was developed and then run through an inverse FE algorithm to obtain subject-specific constituent material properties, such that the structural response was accurate.Results:Experimentally, a log-linear relationship between IVD stiffness and strain rate was observed. The material properties obtained through the subject-specific inverse FE optimization of the anulus fibrosus (AF) fiber and AF fiber ground matrix allowed a good match between the experimental and FE response. This resulted in a Young’s Modulus of AF fibers (YMAF - MPa) to strain rate (ε  - /s) relationship of YMAF=31.5ln(ε  )+435.5, and the C10 parameter of the Neo-Hookean material model of the AF ground matrix was found to be strain-rate independent with an average value of 0.68 MPa.Conclusions:These material properties can be used to improve the accuracy, and therefore predictive ability of FE models of the spine that are used in a wide range of research areas and clinical applications.Clinical SignificanceFinite element models can be used for many applications including investigating low-back p
AU  - Newell,N
AU  - Carpanen,D
AU  - Grigoriadis,G
AU  - Little,JP
AU  - Masouros,S
DO  - 10.1016/j.spinee.2019.07.012
EP  - 2024
PY  - 2019///
SN  - 1529-9430
SP  - 2013
TI  - Material properties of human lumbar intervertebral discs across strain rates
T2  - Spine Journal
UR  - http://dx.doi.org/10.1016/j.spinee.2019.07.012
UR  - https://www.sciencedirect.com/science/article/pii/S1529943019308939?via%3Dihub
UR  - http://hdl.handle.net/10044/1/71583
VL  - 19
ER  -
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