76 results found
Mostowy S, Behr MA, 2005, The origin and evolution of Mycobacterium tuberculosis, CLINICS IN CHEST MEDICINE, Vol: 26, Pages: 207-+, ISSN: 0272-5231
Spreadbury CL, Pallen MJ, Overton T, et al., 2005, Point mutations in the DNA- and cNMP-binding domains of the homologue of the cAMP receptor protein (CRP) in Mycobacterium bovis BCG: implications for the inactivation of a global regulator and strain attenuation, MICROBIOLOGY-SGM, Vol: 151, Pages: 547-556, ISSN: 1350-0872
Koivula T, Ekman M, Leitner T, et al., 2004, Genetic characterization of the Guinea-Bissau family of Mycobacterium tuberculosis complex strains, MICROBES AND INFECTION, Vol: 6, Pages: 272-278, ISSN: 1286-4579
Mostowy S, Cleto C, Sherman DR, et al., 2004, The Mycobacterium tuberculosis complex transcriptome of attenuation, TUBERCULOSIS, Vol: 84, Pages: 197-204, ISSN: 1472-9792
Mostowy S, Cousins D, Behr MA, 2004, Genomic interrogation of the dassie bacillus reveals it as a unique RD1 mutant within the Mycobacterium tuberculosis complex., J Bacteriol, Vol: 186, Pages: 104-109, ISSN: 0021-9193
Despite their remarkable genetic homology, members of the Mycobacterium tuberculosis complex express very different phenotypes, most notably in their spectra of clinical presentation. For example, M. tuberculosis is regarded as pathogenic to humans, whereas members having deleted RD1, such as Mycobacterium microti and Mycobacterium bovis BCG, are not. The dassie bacillus, an infrequent variant of the M. tuberculosis complex characterized as being most similar to M. microti, is the causative agent of tuberculosis (TB) in the dassie (Procavia capensis). Intriguingly, the dassie bacillus is not pathogenic to rabbits or guinea pigs and has never been documented to infect humans. Although it was identified more than a half-century ago, the reasons behind its attenuation are unknown. Because large sequence polymorphisms have presented themselves as the most obvious genomic distinction among members of the M. tuberculosis complex, the DNA content of the dassie bacillus was interrogated by Affymetrix GeneChip to identify regions that are absent from it but present in M. tuberculosis H37Rv. Comparison has led to the identification of nine regions of difference (RD), five of which are shared with M. microti (RDs 3, 7, 8, 9, and 10). Although the dassie bacillus does not share the other documented deletions in M. microti (RD1(mic), RD5(mic), MID1, MID2, and MID3), it has endured unique deletions in the regions of RD1, RD5, N-RD25, and Rv3081-Rv3082c (virS). RD1(das), affecting only Rv3874-Rv3877, is the smallest natural deletion of the RD1 region uncovered and points to genes within this region that are likely implicated in virulence. Newfound deletions from the dassie bacillus are discussed in relation to their evolutionary and biological significance.
Mostowy S, Cousins D, Behr MA, 2004, Genomic interrogation of the dassie bacillus reveals it as a unique RD1 mutant within the Mycobacterium tuberculosis complex, JOURNAL OF BACTERIOLOGY, Vol: 186, Pages: 104-109, ISSN: 0021-9193
Mostowy S, Onipede A, Gagneux S, et al., 2004, Genomic analysis distinguishes Mycobacterium africanum, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 42, Pages: 3594-3599, ISSN: 0095-1137
Nguyen D, Brassard P, Menzies D, et al., 2004, Genomic characterization of an endemic Mycobacterium tuberculosis strain: Evolutionary and epidemiologic implications, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 42, Pages: 2573-2580, ISSN: 0095-1137
Semret M, Zhai G, Mostowy S, et al., 2004, Extensive genomic polymorphism within Mycobacterium avium, JOURNAL OF BACTERIOLOGY, Vol: 186, Pages: 6332-6334, ISSN: 0021-9193
Semret M, Zhai G, Cleto C, et al., 2003, Assembly and validation of a whole genome DNA microarray for members of the Mycobacterium avium complex, 7th International Colloquium on Paratuberculosis, Publisher: INT ASSOC PARATUBERCULOSIS INC, Pages: 233-238
Mostowy S, Behr MA, 2002, Comparative genomics in the fight against tuberculosis: diagnostics, epidemiology, and BCG vaccination., Am J Pharmacogenomics, Vol: 2, Pages: 189-196, ISSN: 1175-2203
Although the causative agent of tuberculosis, Mycobacterium tuberculosis, has been known for some 120 years, the disease continues to plague humanity. In 1998, the sequencing of M. tuberculosis H37Rv enabled tuberculosis researchers to draw comparisons between it and other species of the closely-related M. tuberculosis complex, including bacillus Calmette-Guerin (BCG), the vaccine administered to prevent human tuberculosis. These efforts have uncovered genomic variability that potentially encodes the discrepant phenotypes displayed by species. Due to the infrequency of single nucleotide polymorphisms (SNPs) and other modes of genomic change, large sequence polymorphisms (LSPs) have presented themselves as the most obvious form of genomic variability among species. This review discusses genomic polymorphism among species of the M. tuberculosis complex as revealed through comparative genomics. Attention is drawn towards the impact of comparative genomics in generating several exciting hypotheses towards diagnosis, epidemiology, and prevention of tuberculosis disease.
Mostowy S, Cousins D, Brinkman J, et al., 2002, Genomic deletions suggest a phylogeny for the Mycobacterium tuberculosis complex, JOURNAL OF INFECTIOUS DISEASES, Vol: 186, Pages: 74-80, ISSN: 0022-1899
Roff DA, Mostowy S, Fairbairn DJ, 2002, The evolution of trade-offs: Testing predictions on response to selection and environmental variation, EVOLUTION, Vol: 56, Pages: 84-95, ISSN: 0014-3820
Torraca V, Mostowy S, Zebrafish Infection: from Pathogenesis to Cell Biology, Trends in Cell Biology, ISSN: 0962-8924
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