Imperial College London

DrSergeMostowy

Faculty of MedicineDepartment of Medicine

Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3072s.mostowy

 
 
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Location

 

2.42Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Krokowski:2016:10.1080/15548627.2016.1228496,
author = {Krokowski, S and Lobato-Márquez, D and Mostowy, S},
doi = {10.1080/15548627.2016.1228496},
journal = {Autophagy},
pages = {1--2},
title = {Mitochondria promote septin assembly into cages that entrap Shigella for autophagy.},
url = {http://dx.doi.org/10.1080/15548627.2016.1228496},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Septins are cytoskeletal proteins implicated in cytokinesis and host-pathogen interactions. During macroautophagy/autophagy of Shigella flexneri, septins assemble into cage-like structures to entrap actin-polymerizing bacteria and restrict their dissemination. How septins assemble to entrap bacteria is not fully known. We discovered that mitochondria support septin cage assembly to promote autophagy of Shigella. Consistent with roles for the cytoskeleton in mitochondrial dynamics, we showed that DNM1L/DRP1 (dynamin 1 like) can interact with septins to enhance mitochondrial fission. Remarkably, Shigella fragment mitochondria and escape from septin cage entrapment in order to avoid autophagy. These results uncover a close relationship between mitochondria and septin assembly, and identify a new role for mitochondria in bacterial autophagy.
AU - Krokowski,S
AU - Lobato-Márquez,D
AU - Mostowy,S
DO - 10.1080/15548627.2016.1228496
EP - 2
PY - 2016///
SP - 1
TI - Mitochondria promote septin assembly into cages that entrap Shigella for autophagy.
T2 - Autophagy
UR - http://dx.doi.org/10.1080/15548627.2016.1228496
UR - https://www.ncbi.nlm.nih.gov/pubmed/27629779
UR - http://hdl.handle.net/10044/1/40422
ER -