For the past twelve years I have worked for Target Malaria (www.targetmalaria.org), a research consortium focussed on developing novel genetic gene-drive methods for malaria vector control. As a mosquito population geneticist, my role in the consortium concerns ensuring that the methods can be applied to natural mosquito populations, by taking into account genetic variation in target populations. I work closely with our genetic engineers in South Kensington, and our collaborators at our field sites in Mali, Burkina Faso and Uganda. I am using genomic data from wild and colony Anopheles gambiae, and from across the Anopheles genus, to look for highly conserved genomic regions to aid the selection of genes suitable to be targeted for mosquito control. I study mosquito samples from each field site to characterise the mosquito species present, and am using genomic sequencing data to estimate gene flow, population size and mosquito dispersal, all of which are important considerations for a genetic control method. I also have an active role in developing standard operating procedures for the project, and participate in problem formulation and risk management discussions.
et al., 2017, Genetic diversity of the African malaria vector Anopheles gambiae, Nature, Vol:552, ISSN:0028-0836, Pages:96-100
et al., 2016, A CRISPR-Cas9 sex-ratio distortion system for genetic control, Scientific Reports, Vol:6, ISSN:2045-2322
et al., 2016, Genomic signatures of population decline in the malaria mosquito Anopheles gambiae, Malaria Journal, Vol:15, ISSN:1475-2875
et al., 2016, Partitioning the contributions of alternative malaria vector species, Malaria Journal, Vol:15, ISSN:1475-2875
et al., 2015, AN ANALYSIS OF CHROMOSOMAL INVERSIONS WITHIN THE ANOPHELES 1000-GENOMES PROJECT - MARKERS OF POPULATION STRUCTURE IN DISEASE VECTORS FROM THE PAST TO THE FUTURE, AMER SOC TROP MED & HYGIENE, Pages:423-423, ISSN:0002-9637