Imperial College London
Alternate

Samraat Pawar

Faculty of Natural Sciences, Department of Life Sciences (Silwood Park)

Professor of Theoretical Ecology
 
 
 
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Contact

 

+44 (0)20 7594 2213s.pawar CV

 
 
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Location

 

2.4KennedySilwood Park

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Summary

 

Publications

Citation

BibTex format

@article{Kontopoulos:2020:10.1101/2020.10.13.337972,
author = {Kontopoulos, D-G and Patmanidis, I and Barraclough, TG and Pawar, S},
doi = {10.1101/2020.10.13.337972},
title = {Higher temperatures worsen the effects of mutations on protein stability},
url = {http://dx.doi.org/10.1101/2020.10.13.337972},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Understanding whether and how temperature increases alter the effects of mutations on protein stability is crucial for understanding the limits to thermal adaptation by organisms. Currently, it is generally assumed that the stability effects of mutations are independent of temperature. Yet, mutations should become increasingly destabilizing as temperature rises due to the increase in the energy of atoms. Here, by performing an extensive computational analysis on the essential enzyme adenylate kinase in prokaryotes, we show, for the first time, that mutations become more destabilizing with temperature both across and within species. Consistent with these findings, we find that substitution rates of prokaryotes decrease nonlinearly with temperature. Our results suggest that life on Earth likely originated in a moderately thermophilic and thermally fluctuating environment, and indicate that global warming should decrease the per-generation rate of molecular evolution of prokaryotes.</jats:p>
AU  - Kontopoulos,D-G
AU  - Patmanidis,I
AU  - Barraclough,TG
AU  - Pawar,S
DO  - 10.1101/2020.10.13.337972
PY  - 2020///
TI  - Higher temperatures worsen the effects of mutations on protein stability
UR  - http://dx.doi.org/10.1101/2020.10.13.337972
ER  -
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