Imperial College London
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ProfessorSanjayPrasad

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiomyopathy
 
 
 
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Contact

 

+44 (0)20 7352 8121s.prasad

 
 
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Location

 

CMR UnitRoyal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tayal:2020:10.1002/ejhf.1734,
author = {Tayal, U and Wage, R and Newsome, S and Manivarmane, R and Izgi, C and Muthumala, A and Dungu, JN and Assomull, R and Hatipoglu, S and Halliday, BP and Lota, AS and Ware, JS and Gregson, J and Frenneaux, M and Cook, SA and Pennell, DJ and Scott, AD and Cleland, JGF and Prasad, SK},
doi = {10.1002/ejhf.1734},
journal = {European Journal of Heart Failure},
pages = {1160--1170},
title = {Predictors of left ventricular remodelling in patients with dilated cardiomyopathy - a cardiovascular magnetic resonance study},
url = {http://dx.doi.org/10.1002/ejhf.1734},
volume = {22},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AimsThere is an important need for better biomarkers to predict left ventricular (LV) remodelling in dilated cardiomyopathy (DCM). We undertook a comprehensive assessment of cardiac structure and myocardial composition to determine predictors of remodelling.Methods and resultsProspective study of patients with recentonset DCM with cardiovascular magnetic resonance (CMR) assessment of ventricular structure and function, extracellular volume (T1 mapping), myocardial strain, myocardial scar (late gadolinium enhancement) and contractile reserve (dobutamine stress). Regression analyses were used to evaluate predictors of change in LV ejection fraction (LVEF) over 12 months. We evaluated 56 participants (34 DCM patients, median LVEF 43%; 22 controls). Absolute LV contractile reserve predicted change in LVEF (1% increase associated with 0.4% increase in LVEF at 12 months, P = 0.02). Baseline myocardial strain (P = 0.39 global longitudinal strain), interstitial myocardial fibrosis (P = 0.41), replacement myocardial fibrosis (P = 0.25), and right ventricular contractile reserve (P = 0.17) were not associated with LV reverse remodelling. There was a poor correlation between contractile reserve and either LV extracellular volume fraction (r = −0.22, P = 0.23) or baseline LVEF (r = 0.07, P = 0.62). Men were more likely to experience adverse LV remodelling (P = 0.01) but age (P = 0.88) and diseasemodifying heart failure medication (betablocker, P = 0.28; angiotensinconverting enzyme inhibitor, P = 0.92) did not predict followup LVEF.ConclusionsSubstantial recovery of LV function occurs within 12 months in most patients with recentonset DCM. Women had the greatest improvement in LVEF. A low LV contractile reserve measured by dobutamine stress CMR appears to identify patients whose LVEF is less likely to recover.
AU  - Tayal,U
AU  - Wage,R
AU  - Newsome,S
AU  - Manivarmane,R
AU  - Izgi,C
AU  - Muthumala,A
AU  - Dungu,JN
AU  - Assomull,R
AU  - Hatipoglu,S
AU  - Halliday,BP
AU  - Lota,AS
AU  - Ware,JS
AU  - Gregson,J
AU  - Frenneaux,M
AU  - Cook,SA
AU  - Pennell,DJ
AU  - Scott,AD
AU  - Cleland,JGF
AU  - Prasad,SK
DO  - 10.1002/ejhf.1734
EP  - 1170
PY  - 2020///
SN  - 1388-9842
SP  - 1160
TI  - Predictors of left ventricular remodelling in patients with dilated cardiomyopathy - a cardiovascular magnetic resonance study
T2  - European Journal of Heart Failure
UR  - http://dx.doi.org/10.1002/ejhf.1734
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000513177600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.1734
UR  - http://hdl.handle.net/10044/1/77060
VL  - 22
ER  -
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