Imperial College London

ProfessorSivarameshWigneshweraraj

Faculty of MedicineDepartment of Medicine

Professor of Molecular Microbiology
 
 
 
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Contact

 

+44 (0)20 7594 1867s.r.wig

 
 
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Location

 

4.40BFlowers buildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

72 results found

Sheppard C, Camara B, Shadrin A, Akulenko N, Liu M, Baldwin G, Severinov K, Cota E, Matthews S, Wigneshweraraj SRet al., 2011, Reprint of: Inhibition of Escherichia coli RNAp by T7 Gp2 protein: Role of Negatively Charged Strip of Amino Acid Residues in Gp2, JOURNAL OF MOLECULAR BIOLOGY, Vol: 412, Pages: 832-841, ISSN: 0022-2836

JOURNAL ARTICLE

Sheppard C, Camara B, Shadrin A, Akulenko N, Lu M, Baldwin G, Severinov K, Cota E, Matthews S, Wigneshweraraj SRet al., 2011, Inhibition of Escherichia coli RNAp by T7 Gp2 Protein: Role of Negatively Charged Strip of Amino Acid Residues in Gp2, JOURNAL OF MOLECULAR BIOLOGY, Vol: 407, Pages: 623-632, ISSN: 0022-2836

JOURNAL ARTICLE

Camara B, Liu M, Reynolds J, Shadrin A, Liu B, Kwok K, Simpson P, Weinzierl R, Severinov K, Cota E, Matthews S, Wigneshweraraj SRet al., 2010, T7 phage protein Gp2 inhibits the Escherichia coli RNA polymerase by antagonizing stable DNA strand separation near the transcription start site, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 2247-2252, ISSN: 0027-8424

JOURNAL ARTICLE

Cordes T, Santoso Y, Tomescu AI, Gryte K, Hwang LC, Camara B, Wigneshweraraj S, Kapanidis ANet al., 2010, Sensing DNA Opening in Transcription Using Quenchable Forster Resonance Energy Transfer, BIOCHEMISTRY, Vol: 49, Pages: 9171-9180, ISSN: 0006-2960

JOURNAL ARTICLE

Burrows PC, Joly N, Cannon WV, Camara BP, Rappas M, Zhang X, Dawes K, Nixon BT, Wigneshweraraj SR, Buck Met al., 2009, Coupling sigma Factor Conformation to RNA Polymerase Reorganisation for DNA Melting, JOURNAL OF MOLECULAR BIOLOGY, Vol: 387, Pages: 306-319, ISSN: 0022-2836

JOURNAL ARTICLE

Xiao Y, Wigneshweraraj SR, Weinzierl R, Wang Y-P, Buck Met al., 2009, Construction and functional analyses of a comprehensive Sigma(54) site-directed mutant library using alanine-cysteine mutagenesis, NUCLEIC ACIDS RESEARCH, Vol: 37, Pages: 4482-4497, ISSN: 0305-1048

JOURNAL ARTICLE

Zhang N, Joly N, Burrows PC, Jovanovic M, Wigneshweraraj SR, Buck Met al., 2009, The role of the conserved phenylalanine in the sigma(54)-interacting GAFTGA motif of bacterial enhancer binding proteins, NUCLEIC ACIDS RESEARCH, Vol: 37, Pages: 5981-5992, ISSN: 0305-1048

JOURNAL ARTICLE

Bose D, Pape T, Burrows PC, Rappas M, Wigneshweraraj SR, Buck M, Zhang Xet al., 2008, Organization of an Activator-Bound RNA Polymerase Holoenzyme, MOLECULAR CELL, Vol: 32, Pages: 337-346, ISSN: 1097-2765

JOURNAL ARTICLE

Burrows PC, Wigneshweraraj S, Bose D, Joly N, Schumacher J, Rappas M, Pape T, Stockley PG, Zhang X, Buck Met al., 2008, Visualizing the organization and reorganization of transcription complexes for gene expression, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 36, Pages: 776-779, ISSN: 0300-5127

JOURNAL ARTICLE

Burrows PC, Wigneshweraraj SR, Buck M, 2008, Protein-DNA interactions that govern AAA(+) activator-dependent bacterial transcription initiation, JOURNAL OF MOLECULAR BIOLOGY, Vol: 375, Pages: 43-58, ISSN: 0022-2836

JOURNAL ARTICLE

Wigneshweraraj S, Bose D, Burrows PC, Joly N, Schumacher J, Rappas M, Pape T, Zhang X, Stockley P, Severinov K, Buck Met al., 2008, Modus operandi of the bacterial RNA polymerase containing the sigma(54) promoter-specificity factor, MOLECULAR MICROBIOLOGY, Vol: 68, Pages: 538-546, ISSN: 0950-382X

JOURNAL ARTICLE

Wigneshweraraj S, Burrows P, Bose D, Cannon W, Joly N, Rappas M, Schumacher J, Zhang X, Buck Met al., 2008, THE MECHANISTIC BASIS OF nif GENE ACTIVATION, Joint Conference of the 15th International Congress on Nitrogen Fixation/12 International Conference of the African-Association-for-Biological-Nitrogen-Fixation, Publisher: SPRINGER, Pages: 339-+, ISSN: 0924-1949

CONFERENCE PAPER

Dago AE, Wigneshweraraj SR, Buck M, Morett Eet al., 2007, A role for the conserved GAFTGA motif of AAA plus transcription activators in sensing promoter DNA conformation, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 1087-1097, ISSN: 0021-9258

JOURNAL ARTICLE

Heilemann M, Lymperopoulos K, Wigneshweraraj SR, Buck M, Kapanidis ANet al., 2007, Studying sigma(54)-dependent transcription at the single-molecule level using alternating-laser excitation (ALEX) spectroscopy, Biophotonics 2007 Conference, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

CONFERENCE PAPER

Joly N, Rappas M, Wigneshweraraj SR, Zhang X, Buck Met al., 2007, Coupling nucleotide hydrolysis to transcription activation performance in a bacterial enhancer binding protein, MOLECULAR MICROBIOLOGY, Vol: 66, Pages: 583-595, ISSN: 0950-382X

JOURNAL ARTICLE

Schumacher J, Joly N, Rappas M, Bradley D, Wigneshweraraj SR, Zhang X, Buck Met al., 2007, Sensor I threonine of the AAA plus ATPase transcriptional activator PspF is involved in coupling nucleoticle triphosphate hydrolysis to the restructuring of sigma(54)-RNA polymerase, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 9825-9833, ISSN: 0021-9258

JOURNAL ARTICLE

Buck M, Bose D, Burrows P, Cannon W, Joly N, Pape T, Rappas M, Schumacher J, Wigneshweraraj S, Zhang Xet al., 2006, A second paradigm for gene activation in bacteria, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 34, Pages: 1067-1071, ISSN: 0300-5127

JOURNAL ARTICLE

Leach RN, Gell C, Wigneshweraraj S, Buck M, Smith A, Stockley PGet al., 2006, Mapping ATP-dependent activation at sigma(54) promoter, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 281, Pages: 33717-33726, ISSN: 0021-9258

JOURNAL ARTICLE

Wigneshweraraj SR, Savalia D, Severinov K, Buck Met al., 2006, Interplay between the beta ' clamp and the beta ' jaw domains during DNA opening by the bacterial RNA polymerase at sigma(54)-dependent promoters, JOURNAL OF MOLECULAR BIOLOGY, Vol: 359, Pages: 1182-1195, ISSN: 0022-2836

JOURNAL ARTICLE

Rappas M, Schumacher J, Beuron F, Niwa H, Bordes P, Wigneshweraraj S, Keetch CA, Robinson CV, Buck M, Zhang XDet al., 2005, Structural insights into the activity of enhancer-binding proteins, SCIENCE, Vol: 307, Pages: 1972-1975, ISSN: 0036-8075

JOURNAL ARTICLE

Wigneshweplaraj SR, Burrows PC, Bordes P, Schumacher J, Rappas M, Finn RD, Cannon WV, Zhang X, Buck Met al., 2005, The second paradigm for activation of transcription, PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 79, Vol: 79, Pages: 339-369, ISSN: 0079-6603

JOURNAL ARTICLE

Wigneshweraraj SR, Burrows PC, Bordes P, Schumacher J, Rappas M, Finn RD, Cannon WV, Zhang X, Buck Met al., 2005, The structural basis for nif gene activation, 14th International Nitrogen Fixation Congress, Publisher: SPRINGER, Pages: 59-63

CONFERENCE PAPER

Wigneshweraraj SR, Burrows PC, Severinov K, Buck Met al., 2005, Stable DNA opening within open promoter complexes is mediated by the RNA polymerase beta '-jaw domain, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 280, Pages: 36176-36184, ISSN: 0021-9258

JOURNAL ARTICLE

Bordes P, Wigneshweraraj SR, Chaney M, Dago AE, Morett E, Buck Met al., 2004, Communication between E sigma(54), promoter DNA and the conserved threonine residue in the GAFTGA motif of the PspF sigma(54)-dependent activator during transcription activation, MOLECULAR MICROBIOLOGY, Vol: 54, Pages: 489-506, ISSN: 0950-382X

JOURNAL ARTICLE

Bordes P, Wigneshweraraj SR, Zhang XD, Buck Met al., 2004, sigma(54)-dependent transcription activator phage shock protein F of Escherichia coli: a fragmentation approach to identify sequences that contribute to self-association, BIOCHEMICAL JOURNAL, Vol: 378, Pages: 735-744, ISSN: 0264-6021

JOURNAL ARTICLE

Burrows PC, Severinov K, Buck M, Wigneshweraraj SRet al., 2004, Reorganisation of an RNA polymerase-promoter DNA complex for DNA melting, EMBO JOURNAL, Vol: 23, Pages: 4253-4263, ISSN: 0261-4189

JOURNAL ARTICLE

Wigneshweraraj SR, Burrows PC, Nechaev S, Zenkin N, Severinov K, Buck Met al., 2004, Regulated communication between the upstream face of RNA polymerase and the beta ' subunit jaw domain, EMBO JOURNAL, Vol: 23, Pages: 4264-4274, ISSN: 0261-4189

JOURNAL ARTICLE

Bordes P, Wigneshweraraj SR, Schumacher J, Zhang XD, Chaney M, Buck Met al., 2003, The ATP hydrolyzing transcription activator phage shock protein F of Escherichia coli: Identifying a surface that binds sigma(54), PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 100, Pages: 2278-2283, ISSN: 0027-8424

JOURNAL ARTICLE

Burrows PC, Severinov K, Ishihama A, Buck M, Wigneshweraraj SRet al., 2003, Mapping sigma(54)-RNA polymerase interactions at the -24 consensus promoter element, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 29728-29743, ISSN: 0021-9258

JOURNAL ARTICLE

Cannon W, Bordes P, Wigneshweraraj SR, Buck Met al., 2003, Nucleotide-dependent triggering of RNA polymerase-DNA interactions by an AAA regulator of transcription, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 19815-19825, ISSN: 0021-9258

JOURNAL ARTICLE

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