Imperial College London
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Professor Ramesh Wigneshweraraj

Faculty of Medicine, Department of Infectious Disease

Professor of Molecular Microbiology
 
 
 
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Contact

 

+44 (0)20 7594 1867s.r.wig

 
 
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Location

 

4.40BFlowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tabib-Salazar:2019:10.1016/j.jmb.2019.02.008,
author = {Tabib-Salazar, A and Mulvenna, N and Severinov, K and Matthews, SJ and Wigneshweraraj, S},
doi = {10.1016/j.jmb.2019.02.008},
journal = {Journal of Molecular Biology},
pages = {4078--4092},
title = {Xenogeneic regulation of the bacterial transcription machinery},
url = {http://dx.doi.org/10.1016/j.jmb.2019.02.008},
volume = {431},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The parasitic life cycle of viruses involves the obligatory subversion of the host's macromolecular processes for efficient viral progeny production. Viruses that infect bacteria, bacteriophages (phages), are no exception and have evolved sophisticated ways to control essential biosynthetic machineries of their bacterial prey to benefit phage development. The xenogeneic regulation of bacterial cell function is a poorly understood area of bacteriology. The activity of the bacterial transcription machinery, the RNA polymerase (RNAP), is often regulated by a variety of mechanisms involving small phage-encoded proteins. In this review, we provide a brief overview of known phage proteins that interact with the bacterial RNAP and compare how two prototypical phages of Escherichia coli, T4 and T7, use small proteins to 'puppeteer' the bacterial RNAP to ensure a successful infection.
AU  - Tabib-Salazar,A
AU  - Mulvenna,N
AU  - Severinov,K
AU  - Matthews,SJ
AU  - Wigneshweraraj,S
DO  - 10.1016/j.jmb.2019.02.008
EP  - 4092
PY  - 2019///
SN  - 0022-2836
SP  - 4078
TI  - Xenogeneic regulation of the bacterial transcription machinery
T2  - Journal of Molecular Biology
UR  - http://dx.doi.org/10.1016/j.jmb.2019.02.008
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30776429
UR  - http://hdl.handle.net/10044/1/67834
VL  - 431
ER  -
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