Imperial College London
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Professor Ramesh Wigneshweraraj

Faculty of Medicine, Department of Infectious Disease

Professor of Molecular Microbiology
 
 
 
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Contact

 

+44 (0)20 7594 1867s.r.wig

 
 
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Location

 

4.40BFlowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Krishna:2020:10.1002/mbo3.1058,
author = {Krishna, A and Liu, B and Peacock, SJ and Wigneshweraraj, S},
doi = {10.1002/mbo3.1058},
journal = {MicrobiologyOpen},
pages = {1--8},
title = {The prevalence and implications of single-nucleotide polymorphisms in genes encoding 3 the RNA polymerase of clinical isolates of Staphylococcus aureus},
url = {http://dx.doi.org/10.1002/mbo3.1058},
volume = {9},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Central to the regulation of bacterial gene expression is the multisubunit enzyme RNA polymerase (RNAP), which is responsible for catalyzing transcription. As all adaptive processes are underpinned by changes in gene expression, the RNAP can be considered the major mediator of any adaptive response in the bacterial cell. In bacterial pathogens, theoretically, single nucleotide polymorphisms (SNPs) in genes that encode subunits of the RNAP and associated factors could mediate adaptation and confer a selective advantage to cope with biotic and abiotic stresses. We investigated this possibility by undertaking a systematic survey of SNPs in genes encoding the RNAP and associated factors in a collection of 1,429 methicillinresistant Staphylococcus aureus (MRSA) clinical isolates. We present evidence for the existence of several, hitherto unreported, nonsynonymous SNPs in genes encoding the RNAP and associated factors of MRSA ST22 clinical isolates and propose that the acquisition of amino acid substitutions in the RNAP could represent an adaptive strategy that contributes to the pathogenic success of MRSA.
AU  - Krishna,A
AU  - Liu,B
AU  - Peacock,SJ
AU  - Wigneshweraraj,S
DO  - 10.1002/mbo3.1058
EP  - 8
PY  - 2020///
SN  - 2045-8827
SP  - 1
TI  - The prevalence and implications of single-nucleotide polymorphisms in genes encoding 3 the RNA polymerase of clinical isolates of Staphylococcus aureus
T2  - MicrobiologyOpen
UR  - http://dx.doi.org/10.1002/mbo3.1058
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/mbo3.1058
UR  - http://hdl.handle.net/10044/1/79824
VL  - 9
ER  -
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