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@article{Brown:2014:10.15698/mic2014.09.168,
author = {Brown, DR and Barton, G and Pan, Z and Buck, M and Wigneshweraraj},
doi = {10.15698/mic2014.09.168},
journal = {Microbial Cell},
pages = {315--317},
title = {Combinatorial stress responses: direct coupling of two major stress responses in Escherichia coli},
url = {http://dx.doi.org/10.15698/mic2014.09.168},
volume = {1},
year = {2014}
}

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TY  - JOUR
AB  - Nitrogen is an essential element for all life, and this isno different for the bacterial cell. Numerous cellularmacromolecules contain nitrogen, including proteins,nucleic acids and cell wall components. In Escherichiacoli and related bacteria, the nitrogen stress (Ntr) responseallows cells to rapidly sense and adapt to nitrogenlimitation by scavenging for alternative nitrogensources through the transcriptional activation oftransport systems and catabolic and biosynthetic operonsby the global transcriptional regulator NtrC. Nitrogen-starvedbacterial cells also synthesize the(p)ppGpp effector molecules of a second global bacterialstress response - the stringent response. Recently,we showed that the transcription of relA, the genewhich encodes the major (p)ppGpp synthetase in E.coli, is activated by NtrC during nitrogen starvation.Our results revealed that in E. coli and related bacteria,NtrC functions in combinatorial stress and serves tocouple two major stress responses, the Ntr responseand stringent response.
AU  - Brown,DR
AU  - Barton,G
AU  - Pan,Z
AU  - Buck,M
AU  - Wigneshweraraj
DO  - 10.15698/mic2014.09.168
EP  - 317
PY  - 2014///
SN  - 2311-2638
SP  - 315
TI  - Combinatorial stress responses: direct coupling of two major stress responses in Escherichia coli
T2  - Microbial Cell
UR  - http://dx.doi.org/10.15698/mic2014.09.168
UR  - http://hdl.handle.net/10044/1/28070
VL  - 1
ER  -

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Professor Ramesh Wigneshweraraj

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