Imperial College London
Alternate

ProfessorSalmanRawaf

Faculty of Medicine, School of Public Health

Director of WHO Collaborating Centre
 
 
 
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Contact

 

+44 (0)20 7594 8814s.rawaf

 
 
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Assistant

 

Ms Ela Augustyniak +44 (0)20 7594 8603

 
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Location

 

311Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{GBD:2019:10.1016/S1470-2045(19)30339-0,
author = {GBD, 2017 Childhood Cancer Collaborators},
doi = {10.1016/S1470-2045(19)30339-0},
journal = {Lancet Oncology},
pages = {1211--1225},
title = {The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017},
url = {http://dx.doi.org/10.1016/S1470-2045(19)30339-0},
volume = {20},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Accurate childhood cancer burden data are crucial for resource planning and health policy prioritisation. Model-based estimates are necessary because cancer surveillance data are scarce or non-existent in many countries. Although global incidence and mortality estimates are available, there are no previous analyses of the global burden of childhood cancer represented in disability-adjusted life-years (DALYs). METHODS: Using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 methodology, childhood (ages 0-19 years) cancer mortality was estimated by use of vital registration system data, verbal autopsy data, and population-based cancer registry incidence data, which were transformed to mortality estimates through modelled mortality-to-incidence ratios (MIRs). Childhood cancer incidence was estimated using the mortality estimates and corresponding MIRs. Prevalence estimates were calculated by using MIR to model survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated by multiplying age-specific cancer deaths by the difference between the age of death and a reference life expectancy. DALYs were calculated as the sum of YLLs and YLDs. Final point estimates are reported with 95% uncertainty intervals. FINDINGS: Globally, in 2017, there were 11·5 million (95% uncertainty interval 10·6-12·3) DALYs due to childhood cancer, 97·3% (97·3-97·3) of which were attributable to YLLs and 2·7% (2·7-2·7) of which were attributable to YLDs. Childhood cancer was the sixth leading cause of total cancer burden globally and the ninth leading cause of childhood disease burden globally. 82·2% (82·1-82·2) of global childhood cancer DALYs occurred in low, low-middle, or middle Socio-demographic Index locations, whereas 50·3% (50·3-50·3) of adult cancer DALYs occurred in these same
AU  - GBD,2017 Childhood Cancer Collaborators
DO  - 10.1016/S1470-2045(19)30339-0
EP  - 1225
PY  - 2019///
SN  - 1470-2045
SP  - 1211
TI  - The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017
T2  - Lancet Oncology
UR  - http://dx.doi.org/10.1016/S1470-2045(19)30339-0
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31371206
UR  - https://www.sciencedirect.com/science/article/pii/S1470204519303390?via%3Dihub
UR  - http://hdl.handle.net/10044/1/72512
VL  - 20
ER  -
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