Imperial College London
Alternate

Steven Riley

Faculty of Medicine, School of Public Health

Professor of Infectious Disease Dynamics
 
 
 
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Contact

 

+44 (0)20 7594 2452s.riley

 
 
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Location

 

UG8Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bedford:2015:10.1038/nature14460,
author = {Bedford, T and Riley, S and Barr, IG and Broor, S and Chadha, M and Cox, NJ and Daniels, RS and Gunasekaran, CP and Hurt, AC and Kelso, A and Klimov, A and Lewis, NS and Li, X and McCauley, JW and Odagiri, T and Potdar, V and Rambaut, A and Shu, Y and Skepner, E and Smith, DJ and Suchard, MA and Tashiro, M and Wang, D and Xu, X and Lemey, P and Russell, CA},
doi = {10.1038/nature14460},
journal = {Nature},
pages = {217--U206},
title = {Global circulation patterns of seasonal influenza viruses vary with antigenic drift},
url = {http://dx.doi.org/10.1038/nature14460},
volume = {523},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Understanding the spatiotemporal patterns of emergence and circulation of new human seasonal influenza virus variants is a key scientific and public health challenge. The global circulation patterns of influenza A/H3N2 viruses are well characterized1,2,3,4,5,6,7, but the patterns of A/H1N1 and B viruses have remained largely unexplored. Here we show that the global circulation patterns of A/H1N1 (up to 2009), B/Victoria, and B/Yamagata viruses differ substantially from those of A/H3N2 viruses, on the basis of analyses of 9,604 haemagglutinin sequences of human seasonal influenza viruses from 2000 to 2012. Whereas genetic variants of A/H3N2 viruses did not persist locally between epidemics and were reseeded from East and Southeast Asia, genetic variants of A/H1N1 and B viruses persisted across several seasons and exhibited complex global dynamics with East and Southeast Asia playing a limited role in disseminating new variants. The less frequent global movement of influenza A/H1N1 and B viruses coincided with slower rates of antigenic evolution, lower ages of infection, and smaller, less frequent epidemics compared to A/H3N2 viruses. Detailed epidemic models support differences in age of infection, combined with the less frequent travel of children, as probable drivers of the differences in the patterns of global circulation, suggesting a complex interaction between virus evolution, epidemiology, and human behaviour.
AU  - Bedford,T
AU  - Riley,S
AU  - Barr,IG
AU  - Broor,S
AU  - Chadha,M
AU  - Cox,NJ
AU  - Daniels,RS
AU  - Gunasekaran,CP
AU  - Hurt,AC
AU  - Kelso,A
AU  - Klimov,A
AU  - Lewis,NS
AU  - Li,X
AU  - McCauley,JW
AU  - Odagiri,T
AU  - Potdar,V
AU  - Rambaut,A
AU  - Shu,Y
AU  - Skepner,E
AU  - Smith,DJ
AU  - Suchard,MA
AU  - Tashiro,M
AU  - Wang,D
AU  - Xu,X
AU  - Lemey,P
AU  - Russell,CA
DO  - 10.1038/nature14460
EP  - 206
PY  - 2015///
SN  - 0028-0836
SP  - 217
TI  - Global circulation patterns of seasonal influenza viruses vary with antigenic drift
T2  - Nature
UR  - http://dx.doi.org/10.1038/nature14460
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000357695900036&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/nature14460
VL  - 523
ER  -
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