Publications

BibTex format

@article{Beutler:2005:bfgp/4.3.203,
author = {Beutler, B and Georgel, P and Rutschmann, S and Jiang, Z and Croker, B and Crozat, K},
doi = {bfgp/4.3.203},
journal = {Brief Funct Genomic Proteomic},
pages = {203--213},
title = {Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV).},
url = {http://dx.doi.org/10.1093/bfgp/4.3.203},
volume = {4},
year = {2005}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Innate immunity is inherited and is, therefore, particularly susceptible to analysis by classical genetic methods. The 'phenotype first' approach has already revealed the principal receptors of the innate immune system as well as several essential signalling intermediates. It has recently emerged that innate resistance to mouse cytomegalovirus (MCMV) infection depends upon a large number of host genes with non-redundant functions; hence, random germline mutagenesis frequently causes susceptibility to this pathogen. Approximately one in 30 pedigrees derived from N-ethyl-N-nitrosourea-mutagenised progenitors bears a recessive mutation that disrupts resistance to MCMV. Moreover, many of the genes required for resistance to MCMV will undoubtedly prove to have broad roles in immunity, creating resistance to many other microbes. The forward genetics approach offers an excellent opportunity to identify many of the key components of the innate immune system.
AU  - Beutler,B
AU  - Georgel,P
AU  - Rutschmann,S
AU  - Jiang,Z
AU  - Croker,B
AU  - Crozat,K
DO  - bfgp/4.3.203
EP  - 213
PY  - 2005///
SN  - 1473-9550
SP  - 203
TI  - Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV).
T2  - Brief Funct Genomic Proteomic
UR  - http://dx.doi.org/10.1093/bfgp/4.3.203
UR  - https://www.ncbi.nlm.nih.gov/pubmed/16420746
VL  - 4
ER  -

Download

DrSophieRutschmann

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)