Imperial College London
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DrSophieRutschmann

Faculty of Medicine, Department of Immunology and Inflammation

Reader in Immunology
 
 
 
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Contact

 

s.rutschmann Website

 
 
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Location

 

9N4bHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Beutler:2006:10.1146/annurev.immunol.24.021605.090552,
author = {Beutler, B and Jiang, Z and Georgel, P and Crozat, K and Croker, B and Rutschmann, S and Du, X and Hoebe, K},
doi = {10.1146/annurev.immunol.24.021605.090552},
journal = {Annu Rev Immunol},
pages = {353--389},
title = {Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.},
url = {http://dx.doi.org/10.1146/annurev.immunol.24.021605.090552},
volume = {24},
year = {2006}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Classical genetic methods, driven by phenotype rather than hypotheses, generally permit the identification of all proteins that serve nonredundant functions in a defined biological process. Long before this goal is achieved, and sometimes at the very outset, genetics may cut to the heart of a biological puzzle. So it was in the field of mammalian innate immunity. The positional cloning of a spontaneous mutation that caused lipopolysaccharide resistance and susceptibility to Gram-negative infection led directly to the understanding that Toll-like receptors (TLRs) are essential sensors of microbial infection. Other mutations, induced by the random germ line mutagen ENU (N-ethyl-N-nitrosourea), have disclosed key molecules in the TLR signaling pathways and helped us to construct a reasonably sophisticated portrait of the afferent innate immune response. A still broader genetic screen--one that detects all mutations that compromise survival during infection--is permitting fresh insight into the number and types of proteins that mammals use to defend themselves against microbes.
AU  - Beutler,B
AU  - Jiang,Z
AU  - Georgel,P
AU  - Crozat,K
AU  - Croker,B
AU  - Rutschmann,S
AU  - Du,X
AU  - Hoebe,K
DO  - 10.1146/annurev.immunol.24.021605.090552
EP  - 389
PY  - 2006///
SN  - 0732-0582
SP  - 353
TI  - Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.
T2  - Annu Rev Immunol
UR  - http://dx.doi.org/10.1146/annurev.immunol.24.021605.090552
UR  - https://www.ncbi.nlm.nih.gov/pubmed/16551253
VL  - 24
ER  -
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