Imperial College London
Alternate

ProfessorSejalSaglani

Faculty of Medicine, National Heart & Lung Institute

Professor of Paediatric Respiratory Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3167s.saglani

 
 
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Location

 

112Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Saglani:2019:10.1164/rccm.201810-1956CI,
author = {Saglani, S and Custovic, A},
doi = {10.1164/rccm.201810-1956CI},
journal = {American Journal of Respiratory and Critical Care Medicine},
title = {Childhood asthma: Advances using machine learning and mechanistic studies},
url = {http://dx.doi.org/10.1164/rccm.201810-1956CI},
volume = {199},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A paradigm shift brought by the recognition that childhood asthma is a heterogeneous condition comprising several endotypes underpinned by different pathophysiology, coupled with advances in understanding important causal mechanisms, offers a real opportunity for a step change to reduce the burden of the disease on individual children, families and society. Data-driven approaches have provided a framework for revealing hidden structure within large datasets. One way of bridging findings from data-driven analyses into clinical practice is to link "phenotypes" identified using such techniques with a specific pathology. Epidemiological studies have provided important clues about mechanistic avenues that should be pursued to identify interventions to prevent asthma development or alter its natural history. Findings from cohort studies followed by mechanistic studies in humans and in neonatal mouse models have suggested that environments such as traditional farming may provide protection by modulating innate immune responses, and that impaired innate immunity may increase asthma susceptibility. The key question of which component of these exposures can be translated into interventions requires confirmation. Increasing mechanistic evidence is demonstrating that shaping the airway microbiome in early life may modulate immune function to confer protection. If we are to make advances, we have to foster cross-disciplinary collaborations between data scientists who turn "big data" into useful information about the hidden structures within large dataset which may help disaggregate "asthma", with medical professionals and basic scientists who provide critical clinical and mechanistic insights about the mechanisms underpinning the architecture of the heterogeneity, to deliver mechanism-based stratified treatments and prevention.
AU  - Saglani,S
AU  - Custovic,A
DO  - 10.1164/rccm.201810-1956CI
PY  - 2019///
SN  - 1073-449X
TI  - Childhood asthma: Advances using machine learning and mechanistic studies
T2  - American Journal of Respiratory and Critical Care Medicine
UR  - http://dx.doi.org/10.1164/rccm.201810-1956CI
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30571146
UR  - http://hdl.handle.net/10044/1/66569
VL  - 199
ER  -
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