RESEARCH PROGRAMME
Management of Preschool Wheeze
- Use of molecular profiling to determine optimal management for moderate to severe preschool wheeze - NIHR, Prinicipal Investigator
- Granulocyte activation and functional interactions with the bronchial epithelium and asthma control in children - Asthma UK, Principal Investigator
- Gene-environment interactions mediating preschool wheeze: the role of 17q21, farmyard microbes and innate cytokines - Asthma UK, Principal Investigator
- Patterns of airway infection and inflammation distinguish pathophysiological phenotypes in preschool wheezers independently of symptom pattern - British Lung Foundation, Principal Investigator
Mechanisms mediating Paediatric Severe Asthma
- Role of innate lymphoid cells in mediating severe asthma in children
- Interactions between T helper cells and innate lymphoid cells in steroid resistance in paediatric severe therapy resistant asthma
Collaborations
Breathing Together Study - Wellcome Trust Strategic Award:
Pulmonary epithelial barrier and immunological functions at birth and in early life – key determinants of the development of asthma?, Principal Investigator at Imperial and Chelsea & Westminster Hospital