My research aims to reduce the burden of childhood illness, particularly influencing current trends in early cardiovascular risk and other long term conditions diagnosed in childhood. I lead a team of researchers in the Child Health Unit with funding support from the National Institute of Health Research (NIHR) Programme Development Grants and fellowships. I am also a practising GP in Putney
1. Improving primary care quality for children
This NIHR funded work programme uses clinical electronic records to identify how to improve the management of chronic conditions diagnosed in childhood including asthma, diabetes and inflammatory bowel disease
2. Child obesity and early cardiovascular risk
This work stream explores ways of tackling excess weight in children. The PROMISE programme-( Paediatric Research in Obesity Multi-modal Intervention and Service Evaluation NIHR funded grant in collaboration with UCL/ LSHTM) enabled the largest evaluation of the UK National Childhood Measurement Programme (NCMP) in England and piloting of web based tools to help clinicians to assess growth and guide weight management in children. My US collaboration with Professor Arch Mainous III (University of Florida, U.S.) and Harvard University explores health system approaches to reduce disparities in cardiovascular disease
3. Reducing the burden of infectious illness in children
This theme examines how preventive primary care and antibiotic treatment impacts on infectious illness in children. Current themes are focused on exploring ways of optimising antibiotic prescribing in primary care by developing and validating prescribing rules.
Improving primary care quality for children
Cecil Cowling, T, Bottle A, Wolfe I, Majeed A, Saxena S Access to primary care, visits to emergency departments and unplanned short stay hospital admissions: a cross sectional analysis of children in England 2016 Pediatrics Vol: 137, ISSN: 0031-4005
Giuliani S, Cecil EV, Apelt N, Sharland M, Saxena S. Pediatric Emergency Appendectomy and 30-Day Postoperative Outcomes in District General Hospitals and Specialist Pediatric Surgical Centers in England, April 2001 to March 2012: Retrospective Cohort Study. Annals of Surgery 2015;(1528-1140)
Cecil E, Bottle A, Sharland M, Saxena S. Impact of UK Primary Care Policy Reforms on Short-Stay Unplanned Hospital Admissions for Children With Primary Care-Sensitive Conditions. Annals of Family Medicine 2015; 1544-1717
Chhaya V, Pollok RC, Cecil E, Subramanian V, Curcin V, Majeed A Saxena S. Impact of early thiopurines on surgery in 2770 children and young people diagnosed with inflammatory bowel disease: a national population-based study. Aliment Pharmacol Therapeutics 2015; 1365-2036
Chatu S, Subramanian V, Saxena S, Pollok RC. The Role of Thiopurines in Reducing the Need for Surgical Resection in Crohn's Disease: A Systematic Review and Meta-Analysis. Am J Gastroenterol 2014; 109(1):23-34
Chatu S, Saxena S, Subramanian V, Curcin V, Yadegarfar G, Gunn L et al. The Impact of Timing and Duration of Thiopurine Treatment on First Intestinal Resection in Crohn's Disease: National UK Population-Based Study 1989 to 2010. Am J Gastroenterol 2014
Cecil E, Bottle A, Sharland M, Saxena S. Have contractual changes in primary care affected unplanned short stay childhood admissions in England? National time trends study 2001-11. The Lancet 2013; 382:S3
Child obesity and early cardiovascular risk
Laverty AA, Magee L, Monteiro CA, Saxena S, Millett C et al., 2015, Sugar and artificially sweetened beverage consumption and adiposity changes: National longitudinal study, Int J Behav Nut and Physical Activity Vol: 12, ISSN: 1479-5868
Black JA, Park M, Gregson J, Falconer CL, White B, Kessel A, Saxena S et al. Child obesity cut-offs as derived from parental perceptions: cross-sectional questionnaire. Br J Gen Practice 2015 ;1478-5242.
Jones Nielsen JD, Laverty AA, Millett C, Mainous III AG, Majeed A, Saxena S. Rising Obesity-Related Hospital Admissions among Children and Young People in England: National Time Trends Study. PloS One 2013.
Mainous III AG, Johnson SP, Saxena S,. Inpatient bariatric surgery among eligible black and white men and women in the United States, 1999-2010. Am J Gastroenterol 2013; 108(8):1218-1223.
Post RE, Mainous AG, Gregorie SH, Knoll ME, Diaz VA, Saxena S. The Influence of Physician Acknowledgment of Patients' Weight Status on Patient Perceptions of Overweight and Obesity in the United States. JAMA Int Med 2011; 171(4):316-321.
Reducing the burden of infectious illness in children
Bielicki Sharland Saxena S et al. Not too little, not too much: What approach is best for oral antibiotic dose selection for children?" BMJ 2015 351 h5447
Lau WC, Murray M, Saxena S et al. Impact of pneumococcal conjugate vaccines on childhood otitis media in the United Kingdom. Vaccine 2015;(1873-2518 ).
Saxena S, Ismael Z, Murray ML, Barker C, Wong ICK, Sharland M, Long PFet al., 2014, Oral penicillin prescribing for children in the UK: a comparison with BNF for Children age-band recommendations, British Jourrnal of General Practice Vol: 64, Pages: E217-E222, ISSN: 0960-1643
et al., 2017, Do Thiopurines Reduce the Risk of Surgery in Elderly Onset Inflammatory Bowel Disease? A 20-Year National Population-Based Cohort Study., Inflamm Bowel Dis, Vol:23, Pages:672-680
et al., 2016, Primary Care Access, Emergency Department Visits, and Unplanned Short Hospitalizations in the UK, Pediatrics, Vol:137, ISSN:0031-4005
et al., 2016, Emerging trends and risk factors for perianal surgery in Crohn's disease: a 20-year national population-based cohort study, European Journal of Gastroenterology & Hepatology, Vol:28, ISSN:0954-691X, Pages:890-895
et al., 2016, Steroid dependency and trends in prescribing for inflammatory bowel disease - a 20-year national population-based study, Alimentary Pharmacology & Therapeutics, Vol:44, ISSN:0269-2813, Pages:482-494
Ma RMMN, Saxena S, Cecil E, Can Clinical Practice Research Datalink (CPRD) be used to study trends in recorded abortions in UK general practice?, Faculty of Sexual and Reproductive Healthcare Annual Scientific Conference