Imperial College London
Portrait Picture

ProfessorSoniaSaxena

Faculty of Medicine, School of Public Health

Professor of Primary Care
 
 
 
//

Contact

 

+44 (0)20 7594 0839s.saxena Website

 
 
//

Location

 

332Reynolds BuildingCharing Cross Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Saxena:2019:10.1111/apt.15390,
author = {Saxena, S and Cecil, E and Majeed, A and Blackwell, J and Pollok, R and Alexakis, C},
doi = {10.1111/apt.15390},
journal = {Alimentary Pharmacology and Therapeutics},
pages = {556--567},
title = {The impact of smoking and smoking-cessation on disease outcomes in Ulcerative Colitis: a nationwide population-based study},
url = {http://dx.doi.org/10.1111/apt.15390},
volume = {50},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundSmokers are less likely to develop Ulcerative Colitis (UC) but the impact of smoking and subsequentcessation on clinical outcomes in UC is unclear. Aim: To evaluate the effect of smoking status andsmoking cessation on disease outcomes.MethodsUsing a nationally representative clinical research database, we identified incident cases of UCduring 2005-2016. Patients were grouped as never-smokers, ex-smokers and smokers, based onsmoking status recorded in the two years preceding UC diagnosis. We defined subgroups ofpersistent smokers and smokers who quit within 2 years after diagnosis. We compared rates ofoverall corticosteroid use, corticosteroid-requiring flares, corticosteroid dependency, thiopurineuse, hospitalization and colectomy between these groups.ResultsWe identified 6754 patients with a new diagnosis of UC over the study period with data on smokingstatus, of whom 878 were smokers at diagnosis. Smokers had a similar risk of corticosteroidrequiring flares (OR 1.16, 95%CI 0.92-1.25), thiopurine use (HR 0.84, 95%CI 0.62-1.14),corticosteroid dependency (HR 0.85, 95%CI 0.60-1.11), hospitalization (HR 0.92, 95%CI 0.72-1.18),and colectomy (HR 0.78, 95%CI 0.50-1.21) in comparison with never-smokers.Rates of flares, thiopurine use, corticosteroid dependency, hospitalization and colectomy were notsignificantly different between persistent smokers and those who quit smoking after a diagnosis ofUC.ConclusionsSmokers and never-smokers with UC have similar outcomes with respect to flares, thiopurine use,corticosteroid dependency, hospitalization and colectomy. Smoking cessation was not associatedwith worse disease course. The risks associated with smoking outweigh any benefits. UC patientsshould be counselled against smoking.
AU  - Saxena,S
AU  - Cecil,E
AU  - Majeed,A
AU  - Blackwell,J
AU  - Pollok,R
AU  - Alexakis,C
DO  - 10.1111/apt.15390
EP  - 567
PY  - 2019///
SN  - 0269-2813
SP  - 556
TI  - The impact of smoking and smoking-cessation on disease outcomes in Ulcerative Colitis: a nationwide population-based study
T2  - Alimentary Pharmacology and Therapeutics
UR  - http://dx.doi.org/10.1111/apt.15390
UR  - https://onlinelibrary.wiley.com/doi/full/10.1111/apt.15390
UR  - http://hdl.handle.net/10044/1/71562
VL  - 50
ER  -
Download