Imperial College London

ProfessorSimonSchultz

Faculty of EngineeringDepartment of Bioengineering

Professor of Neurotechnology
 
 
 
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Contact

 

+44 (0)20 7594 1533s.schultz Website

 
 
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Location

 

4.11Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Muzzu:2016:10.1101/078873,
author = {Muzzu, T and Mitolo, S and Gava, G and Schultz, S},
doi = {10.1101/078873},
publisher = {Cold Spring Harbor Laboratory},
title = {Encoding of locomotion kinematics in the mouse cerebellum},
url = {http://dx.doi.org/10.1101/078873},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - UNPB
AB - <jats:p>The cerebellum has a well-established role in locomotion control, but how the cerebellar network regulates locomotion behaviour is still not well understood. We therefore characterized the activity of cerebellar neurons in awake mice engaged in a locomotion task, using high-density silicon electrode arrays. We characterized the activity of over 300 neurons in response to locomotion, finding tuning to speed of locomotion, turning, and phase of the step cycle. We found that the cerebellar neurons we recorded mainly encoded information about future locomotor activity. We were able to decode the speed of locomotion with a simple linear algorithm, needing relatively few well-chosen cells to provide an accurate estimate of locomotion speed. Our observation that cerebellar neuronal activity predicts locomotion in the near future, and encodes the required kinematic variables, points to this activity underlying the efference copy signal for vertebrate locomotion.</jats:p>
AU - Muzzu,T
AU - Mitolo,S
AU - Gava,G
AU - Schultz,S
DO - 10.1101/078873
PB - Cold Spring Harbor Laboratory
PY - 2016///
TI - Encoding of locomotion kinematics in the mouse cerebellum
UR - http://dx.doi.org/10.1101/078873
ER -