Imperial College London


Faculty of EngineeringDepartment of Bioengineering

Professor of Neurotechnology



+44 (0)20 7594 1533s.schultz Website




4.11Royal School of MinesSouth Kensington Campus






BibTex format

author = {Ruz, ID and Schultz, SR},
doi = {10.1101/059493},
publisher = {Cold Spring Harbor Laboratory},
title = {Fractured tonotopy of functional neural clusters in mouse auditory cortex},
url = {},
year = {2016}

RIS format (EndNote, RefMan)

AB - <jats:title>Abstract</jats:title><jats:p>The degree of order versus randomness in mammalian cortical circuits has been the subject of much discussion. Previous reports showed that at a large scale there is smooth tonotopy in mouse auditory cortex, while at the single neuron level the representation is the traditional “salt and pepper” configuration attributed to rodent cortex. Here we show that at the micro columnar scale we find a large variety of response profiles, but neurons tend to share similar preference in terms of frequency, bandwidth and latency. However, this smooth representation was fractured and large differences were possible between neighbouring neurons. Despite the tendency of most groups of neurons to operate redundantly, high information gains were achieved between cells that had a high signal correlation. Connectivity between neurons was highly non-random, in agreement with a previous in-vitro report from layer five. Our results suggest the existence of functional clusters, connecting neighbouring mini-columns. This supports the idea of a “salt and pepper” configuration at the level of functional clusters of neurons rather than single units.</jats:p>
AU - Ruz,ID
AU - Schultz,SR
DO - 10.1101/059493
PB - Cold Spring Harbor Laboratory
PY - 2016///
TI - Fractured tonotopy of functional neural clusters in mouse auditory cortex
UR -
ER -