Imperial College London

ProfessorSimonSchultz

Faculty of EngineeringDepartment of Bioengineering

Professor of Neurotechnology
 
 
 
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Contact

 

+44 (0)20 7594 1533s.schultz Website

 
 
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Location

 

4.11Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Garasto,
author = {Garasto, S and Nicola, W and Bharath, A and Schultz, S and Garasto, S and Nicola, W and Bharath, A and Schultz, S},
publisher = {IEEE},
title = {Neural sampling strategies for visual stimulus reconstruction from two-photon imaging of mouse primary visual cortex},
url = {http://hdl.handle.net/10044/1/67355},
}

RIS format (EndNote, RefMan)

TY  - CPAPER
AB - Interpreting the neural code involves decoding the firing pattern of sensory neurons from the perspective of a downstream population. Performing such a read-out is an essential step for the understanding of sensory information processing in the brain and has implications for Brain-Machine Interfaces. While previous work has focused on classification algorithms to categorize stimuli using a predefined set of labels, less attention has been given to full-stimulus reconstruction, especially from calcium imaging recordings. Here, we attempt a pixel-by-pixel reconstruction of complex natural stimuli from two-photon calcium imaging of 103 neurons in layer 2/3 of mouse primary visual cortex. Using an optimal linear estimator, we investigated which factors drive the reconstruction performance at the pixel level. We find the density of receptive fields to be the most influential feature. Finally, we use the receptive field data and simulations from a linear-nonlinear Poisson model to extrapolate decoding accuracy as a function of network size. Based on our analysis on a public dataset, reconstruction performance using two-photon protocols might be considerably improved if the receptive fields are sampled more uniformly in the full visual field. These results provide practical experimental guidelines to boost the accuracy of full-stimulus reconstruction.
AU - Garasto,S
AU - Nicola,W
AU - Bharath,A
AU - Schultz,S
AU - Garasto,S
AU - Nicola,W
AU - Bharath,A
AU - Schultz,S
PB - IEEE
TI - Neural sampling strategies for visual stimulus reconstruction from two-photon imaging of mouse primary visual cortex
UR - http://hdl.handle.net/10044/1/67355
ER -