Imperial College London


Faculty of MedicineDepartment of Medicine

Emeritus Professor in Infectious Diseases



s.shaunak Website




8.N15Hammersmith HospitalHammersmith Campus





Medicines today 

Making drugs today

PODCAST - BBC Radio 4 - Four Thought - 1 October 2014

(1) TLR4 antagonist for infection

dendrimer glucosamine
(a) Imperial PODCAST in September 2012 
(b) Immunology 2015
(c) Dendrimer drugs for infection & inflammation 2015
(d) EMBO Molecular Medicine 2012 - Editorial
(e) EMBO Molecular Medicine 2012
(f) Nature Biotechnology 2004
(g) PLoS Computational Biology 2011
(h) Biomaterials 2011
(i) Journal Molecular Modelling 2011
(j) Journal Molecular Modelling 2011 (b)
(k) Macromolecules 2009
(l) Macromolecules 2009 (b)

(2) Interferon immuno-therapy

(a) Biomaterials 2011
(b) Nanomedicine 2015
(c) American Journal of Transplantation 2010
(d) American Journal of Transplantation 2010 - Editorial
(e) American Journal of Transplantation 2012     
(f) New Aspergillus Mouse Model 2013    
(g) EMBO Molecular Medicine 2015  

(3) PEGylating THERApeutic proteins

Pegylated protein

(a) Nature Chemical Biology 2006
(b) Nature Protocols 2007
(c) Nature Protocols 2006
(d) Advanced Drug Delivery Reviews 2008
(e) Bioconjugate Chemistry 2006

For this drug discovery achievement & creation of PolyTherics, read the Guardian article & listen to the Imperial podcast.

(1) The Guardian - 2 January 2007
(2) Imperial PODCAST in March 2007.

(4) Blocking HIV-1 entry

(a) Dextrin sulfate & SAINT Study     
(b) Dextrin sulfate & Kaposi's Sarcoma 
(c) Drug Targeting 2003    
(d) Dextrin sulfate Blocks HIV-1 Infection  

(5) Monitoring HIV-1 replication

Viral Res

(a) Nature Medicine 2000   
(b) HIV DNA Circles in the Brain  



Monnery BD, Wright M, Cavill R, et al., 2017, Cytotoxicity of polycations: Relationship of molecular weight and the hydrolytic theory of the mechanism of toxicity, International Journal of Pharmaceutics, Vol:521, ISSN:0378-5173, Pages:249-258

Czaplewski L, Bax R, Clokie M, et al., 2016, Alternatives to antibiotics-a pipeline portfolio review, Lancet Infectious Diseases, Vol:16, ISSN:1473-3099, Pages:239-251

Islam D, Lombardini E, Ruamsap N, et al., 2016, Controlling the cytokine storm in severe bacterial diarrhoea with an oral Toll-like receptor 4 antagonist, Immunology, Vol:147, ISSN:0019-2805, Pages:178-189

Shah A, Kannambath S, Herbst S, et al., 2016, Calcineurin Orchestrates Lateral Transfer of Aspergillus fumigatus during Macrophage Cell Death, American Journal of Respiratory and Critical Care Medicine, Vol:194, ISSN:1073-449X, Pages:1127-1139

Herbst S, Shah A, Moya MM, et al., 2015, Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus, Embo Molecular Medicine, Vol:7, ISSN:1757-4676, Pages:240-258

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