Imperial College London

ProfessorSpencerSherwin

Faculty of EngineeringDepartment of Aeronautics

Professor of Computational Fluid Mechanics
 
 
 
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Contact

 

+44 (0)20 7594 5052s.sherwin Website

 
 
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Location

 

313BCity and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Moore:2009:10.1016/j.jcin.2009.01.010,
author = {Moore, P and Barlis, P and Spiro, J and Ghimire, G and Roughton, M and Di, Mario C and Wallis, W and Ilsley, C and Mitchell, A and Mason, M and Kharbanda, R and Vincent, P and Sherwin, S and Dalby, M},
doi = {10.1016/j.jcin.2009.01.010},
journal = {Journal of the American College of Cardiology Cardiovascular Interventions},
pages = {437--444},
title = {A Randomized Optical Coherence Tomography Study of Coronary Stent Strut Coverage and Luminal Protrusion With Rapamycin-Eluting Stents},
url = {http://dx.doi.org/10.1016/j.jcin.2009.01.010},
volume = {2},
year = {2009}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Objectives We used optical coherence tomography, which has a resolution of <20 mu m, to analyze thin layers of neointima in rapamycin-eluting coronary stents.Background Lack of neointimal coverage has been implicated in the pathogenesis of drug-eluting coronary stent thrombosis. Angiography and intracoronary ultrasound lack the resolution to examine this.Methods We conducted a randomized trial in patients receiving polymer-coated rapamycin-eluting stents (Cypher, Cordis, Johnson & Johnson, Miami, Florida) and nonpolymer rapamycin-eluting stents (Yukon, Translumina, Hechingen, Germany) to examine neointimal thickness, stent strut coverage, and protrusion at 90 days. Twenty-four patients (n = 12 for each group) underwent stent deployment and invasive follow-up at 90 days with optical coherence tomography. The primary end point was binary stent strut coverage. Coprimary end points were neointimal thickness and stent strut luminal protrusion.Results No patient had angiographic restenosis. For polymer-coated and nonpolymer rapamycin-eluting stents, respectively, mean (SD), neointimal thickness was 77.2 (25.6) mu m versus 191.2 (86.7) mu m (p < 0.001). Binary stent strut coverage was 88.3% (11.8) versus 97.2% (6.1) (p = 0.030). Binary stent strut protrusion was 26.5% (17.5) versus 4.8% (8.6) (p = 0.001).Conclusions Mean neointimal thickness for the polymer-coated rapamycin-eluting stent was significantly less than the nonpolymer rapamycin-eluting stent but as a result coverage was not homogenous, with >10% of struts being uncovered. High-resolution imaging allowed development of the concept of the protrusion index, and >25% of struts protruded into the vessel lumen with the polymer-coated rapamycin-eluting stent compared with <5% with the nonpolymer rapamycin-eluting stent. These findings may have important implications for the risk of stent thrombosis and, therefore, future stent design. (An optical coherence tomography study to determine stent coverag
AU - Moore,P
AU - Barlis,P
AU - Spiro,J
AU - Ghimire,G
AU - Roughton,M
AU - Di,Mario C
AU - Wallis,W
AU - Ilsley,C
AU - Mitchell,A
AU - Mason,M
AU - Kharbanda,R
AU - Vincent,P
AU - Sherwin,S
AU - Dalby,M
DO - 10.1016/j.jcin.2009.01.010
EP - 444
PY - 2009///
SN - 1936-8798
SP - 437
TI - A Randomized Optical Coherence Tomography Study of Coronary Stent Strut Coverage and Luminal Protrusion With Rapamycin-Eluting Stents
T2 - Journal of the American College of Cardiology Cardiovascular Interventions
UR - http://dx.doi.org/10.1016/j.jcin.2009.01.010
VL - 2
ER -