Imperial College London

ProfessorSpencerSherwin

Faculty of EngineeringDepartment of Aeronautics

Professor of Computational Fluid Mechanics
 
 
 
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Contact

 

+44 (0)20 7594 5052s.sherwin Website

 
 
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Location

 

313BCity and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vincent:2009:10.1016/j.bpj.2009.01.022,
author = {Vincent, PE and Sherwin, SJ and Weinberg, PD},
doi = {10.1016/j.bpj.2009.01.022},
journal = {Biophysical Journal},
pages = {3102--3115},
title = {The Effect of a Spatially Heterogeneous Transmural Water Flux on Concentration Polarization of Low Density Lipoprotein in Arteries},
url = {http://dx.doi.org/10.1016/j.bpj.2009.01.022},
volume = {96},
year = {2009}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Uptake of low density lipoprotein (LDL) by the arterial wall is likely to play a key role in atherogenesis. A particular process that may cause vascular scale heterogeneity in the rate of transendothelial LDL transport is the formation of a flow-dependent LDL concentration polarization layer on the luminal surface of the arterial endothelium. In this study, the effect of a spatially heterogeneous transmural water flux (that traverses the endothelium only via interendothelial cell clefts) on such concentration polarization is investigated numerically. Unlike in previous investigations, realistic intercellular cleft dimensions are used here and several values of LDL diffusivity are considered. Particular attention is paid to the spatially averaged LDL concentration adjacent to different regions of the endothelial surface, as such measures may be relevant to the rate of transendothelial LDL transport. It is demonstrated in principle that a heterogeneous transmural water flux can act to enhance such measures, and cause them to develop a shear dependence (in addition to that caused by vascular scale flow features, affecting the overall degree of LDL concentration polarization). However, it is shown that this enhancement and additional shear dependence are likely to be negligible for a physiologically realistic transmural flux velocity of 0.0439 mu m s(-1) and an LDL diffusivity (in blood plasma) of 28.67 mu m(2) s(-1). Hence, the results imply that vascular scale studies of LDL concentration polarization are justified in ignoring the effect of a spatially heterogeneous transmural water flux.
AU - Vincent,PE
AU - Sherwin,SJ
AU - Weinberg,PD
DO - 10.1016/j.bpj.2009.01.022
EP - 3115
PY - 2009///
SN - 0006-3495
SP - 3102
TI - The Effect of a Spatially Heterogeneous Transmural Water Flux on Concentration Polarization of Low Density Lipoprotein in Arteries
T2 - Biophysical Journal
UR - http://dx.doi.org/10.1016/j.bpj.2009.01.022
UR - http://www2.imperial.ac.uk/ssherw/spectralhp/papers/BPJ-ViShWe-09.pdf
VL - 96
ER -