Imperial College London

ProfessorSpencerSherwin

Faculty of EngineeringDepartment of Aeronautics

Professor of Computational Fluid Mechanics
 
 
 
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Contact

 

+44 (0)20 7594 5052s.sherwin Website

 
 
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Location

 

313BCity and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vincent:2010:10.1016/j.jtbi.2010.04.015,
author = {Vincent, PE and Sherwin, SJ and Weinberg, PD},
doi = {10.1016/j.jtbi.2010.04.015},
journal = {Journal of Theoretical Biology},
pages = {1--17},
title = {The Effect of the Endothelial Glycocalyx Layer on Concentration Polarisation of Low Density Lipoprotein in Arteries},
url = {http://dx.doi.org/10.1016/j.jtbi.2010.04.015},
volume = {265},
year = {2010}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - It has been postulated that a flow-dependent (and hence spatially varying) low density lipoprotein (LDL) concentration polarisation layer forms on the luminal surface of the vascular endothelium. Such a layer has the potential to cause heterogeneity in the distribution of atherosclerotic lesions by spatially modulating the rate of LDL transport into the arterial wall. Theoretical analysis suggests that a transmural water flux which is spatially heterogeneous at the cellular scale can act to enhance LDL concentration polarisation in a shear dependent fashion. However, such an effect is only observed if a relevant Peclet number (i.e. the ratio of LDL convection to LDL diffusion) is of order unity or greater. Based on the diffusivity of LDL in blood plasma, such a Peclet number is found to be far less than unity, implying that the aforementioned enhancement and shear dependence will not occur. However, this conclusion ignores the existence of the endothelial glycocalyx layer (EGL), which may inhibit the diffusion of LDL near the luminal surface of the endothelium, and hence raise any Peclet number associated with the transport of LDL. The present study numerically investigates the effect of the EGL, as well as a heterogeneous transmural water flux, on arterial LDL concentration polarisation. Particular attention is paid to measures of LDL concentration polarisation thought relevant to the rate of transendothelial LDL transport. It is demonstrated that an EGL is unlikely to cause any additional shear dependence of such measures directly, irrespective of whether or not LDL can penetrate into the EGL. However, it is found that such measures depend significantly on the nature of the interaction between LDL and the EGL (parameterised by the height of the EGL, the depth to which LDL penetrates into the EGL, and the diffusivity of LDL in the EGL). Various processes may regulate the interaction of LDL with the EGL, possibly in a flow dependent and hence spatially non-uniform f
AU - Vincent,PE
AU - Sherwin,SJ
AU - Weinberg,PD
DO - 10.1016/j.jtbi.2010.04.015
EP - 17
PY - 2010///
SN - 0022-5193
SP - 1
TI - The Effect of the Endothelial Glycocalyx Layer on Concentration Polarisation of Low Density Lipoprotein in Arteries
T2 - Journal of Theoretical Biology
UR - http://dx.doi.org/10.1016/j.jtbi.2010.04.015
UR - http://www2.imperial.ac.uk/ssherw/spectralhp/papers/JTB-ViShWe-09.pdf
VL - 265
ER -