Gram Positive Pathogenesis
We research the potential mechanisms by which serious Gram positive pathogens cause disease, using the group A streptococcus (Streptococcus pyogenes) as a paradigm.
S. pyogenes causes a spectrum of disease ranging from pharyngitis to invasive infections such as necrotising fasciitis, peripartum sepsis and toxic shock. In the developing world, S. pyogenes infections are associated with development of rheumatic fever, a major cause of valvular heart disease, and glomerulonephritis.
Our research examines the interface between pathogen molecular microbiology and host immune response, and is informed by extreme phenotypes of infection, and epidemiological trends in disease over time, leading to recognition of the importance of recombination-related genome remodelling in disease frequency, and the impacts that changes in human behaviour might have.
RESEARCH THAT IMPACTS ON PUBLIC HEALTH
- Puerperal sepsis and the Colebrook Study (see Research tab)
- SpyCEP and S. pyogenes virulence
- Molecular anatomy of S. pyogenes and scarlet fever in UK (with PHE & WTSI)
- Immunity to S. pyogenes and vaccine options
- S. pyogenes capsule and host-pathogen interaction
- Staphylococcal toxic shock epidemiology
- Biobank for adult sepsis admissions (with Graham Cooke, Hugo Donaldson)
- Interaction of S. pyogenes with complement
- NIHR HPRU E. coli bacteremia; GBS nosocomial spread; see link above
- Imperial: James Pease (Leukocyte Biology).
- MRC Centre for Molecular Bacteriology and Infection (CMBI). Associate member
- Public Health England (Androulla Efstratiou Theresa Lamagni Angela Kearns Neil Woodford)
- University College London/UCH (Mahdad Noursadeghi) BioAID partner
- University of Oxford (David Jackson)
- University of Lund (Lars Bjork and Inga-Maria Frick)
- University of Auckland (Siouxsie Wiles, John Fraser and Thomas Proft).
- Wellcome Trust Sanger Institute (WTSI: Julian Parkhill, Matthew Holden, Stephen Bentley, David Goulding)
- University of Cambridge (Sharon Peacock)
et al., Emergence of dominant toxigenic M1T1 Streptococcus pyogenes clone during increased scarlet fever activity in England: a population-based molecular epidemiological study, Lancet Infectious Diseases, ISSN:1473-3099
et al., 2017, Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase, PLOS Pathogens, Vol:13, ISSN:1553-7366
et al., 2016, Scarlet Fever Upsurge in England and Molecular-Genetic Analysis in North-West London, 2014, Emerging Infectious Diseases, Vol:22, ISSN:1080-6059
et al., 2016, Development of a multicomponent vaccine for Streptococcus pyogenes based on the antigenic targets of IVIG, Journal of Infection, Vol:72, ISSN:1532-2742, Pages:450-459
et al., 2015, Turner et al. Reply to “Emergence of the Same Successful Clade among Distinct Populations of emm89 Streptococcus pyogenes in Multiple Geographic Regions”, Mbio, Vol:6, ISSN:2161-2129
et al., Rapid lymphatic dissemination of encapsulated group A streptococci via lymphatic vessel endothelial receptor-1 interaction, PLOS Pathogens, Vol:11, ISSN:1553-7366
et al., 2015, Corynebacterium ulcerans cutaneous diphtheria., The Lancet Infectious Diseases, Vol:15, ISSN:1474-4457, Pages:1100-1107
et al., 2015, Emergence of a new highly successful acapsular group A Streptococcus clade of the genotype emm89 in the United Kingdom, Mbio, Vol:6, ISSN:2161-2129
Lamb LEM, Sriskandan S, Tan LKK, 2014, Bromine, bear-claw scratch fasciotomies, and the Eagle effect: management of group A streptococcal necrotising fasciitis and its association with trauma, The Lancet Infectious Diseases, Vol:15, ISSN:1474-4457, Pages:109-121
et al., 2013, RocA truncation underpins hyper-encapsulation, carriage longevity and transmissibility of serotype M18 group A streptococci, Plos Pathogens, Vol:9, ISSN:1553-7374
et al., 2013, Inactivation of the CovR/S Virulence Regulator Impairs Infection in an Improved Murine Model of Streptococcus pyogenes Naso-Pharyngeal Infection, PLOS One, Vol:8, ISSN:1932-6203