Imperial College London

ProfessorShiraneeSriskandan

Faculty of MedicineDepartment of Medicine

Professor of Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 3313 3135s.sriskandan

 
 
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Location

 

8N4CWBHammersmith HospitalHammersmith Campus

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Summary

 

Summary

Gram Positive Pathogenesis

We research the potential mechanisms by which serious Gram positive pathogens cause disease, using the group A streptococcus (Streptococcus pyogenes) as a paradigm. 

Group A strep on agar (Photo: David Goulding WTSI)S. pyogenes causes a spectrum of disease ranging from pharyngitis to invasive infections such as necrotising fasciitis, peripartum sepsis and toxic shock. In the developing world, S. pyogenes infections are associated with development of rheumatic fever, a major cause of valvular heart disease, and glomerulonephritis.

Our research examines the interface between pathogen molecular microbiology and host immune response, and is informed by extreme phenotypes of infection, and epidemiological trends in disease over time, leading to recognition of the importance of recombination-related genome remodelling in disease frequency, and the impacts that changes in human behaviour might have.

SMEZ-2, courtesy Prof Ted Baker, Univ of AucklandOne focus is the role of bacterial superantigens in streptococcal disease, for example, the classical phage-encoded scarlet fever toxins, SPEA  and SPEC, as well as the staphylococcal superantigens that can triggerboth  menstrual and non-menstrual toxic shock. 

 

Cleavage of CXCL8 by SpyCEP

Evasion of the innate immune response is a trademark of S. pyogenes and we have a keen interest in the function and regulation of the CXC chemokine cleaving protease SpyCEP (cepA), as well as interactions with the complement system, and the potential role of capsule loss and gain in progression of disease and interaction with lymphatic system. 

RESEARCH THAT IMPACTS ON PUBLIC HEALTH

 

Professor Sriskandan is theme lead for the NIHR Health Protection Research Unit (HPRU) in Healthcare Associated Infection and Antimicrobial Resistance. Together with Public Health England colleague Neil Woodford, Professor Sriskandan leads the ‘Applied Molecular Bacteriology’ theme, which explores the molecular basis for bacterial infections relevant to the healthcare setting, antimicrobial resistance, and haemolytic streptococal infections that are of public health importance. The HPRU, which was established on 1 April 2014, is a partnership between Imperial College London, Public Health England, Cambridge University Veterinary School, the Wellcome Trust Sanger Institute (WTSI) and Imperial College Health Partners North West London Academic Health Science Network.

CURRENT PROJECTS

  • Puerperal sepsis and the Colebrook Study (see Research tab)
  • SpyCEP and S. pyogenes virulence
  • Molecular anatomy of S. pyogenes and scarlet fever  in UK (with PHE & WTSI)
  • Immunity to S. pyogenes and vaccine options 
  • S. pyogenes capsule and host-pathogen interaction
  • Staphylococcal toxic shock epidemiology 
  • Biobank for adult sepsis admissions  (with Graham Cooke, Hugo Donaldson)
  • Interaction of S. pyogenes with complement  
  • NIHR HPRU  E. coli bacteremia; GBS nosocomial spread; see link above

CUrrent colLaboratIONS

  • Imperial:  James Pease (Leukocyte Biology). 
  • MRC Centre for Molecular Bacteriology and Infection (CMBI). Associate member 
  • Public Health England (Androulla Efstratiou Theresa Lamagni Angela Kearns Neil Woodford)
  • University College London/UCH (Mahdad Noursadeghi) BioAID partner
  • University of Oxford (David Jackson)
  • University of Lund (Lars Bjork and Inga-Maria Frick)  
  • University of Auckland (Siouxsie Wiles, John Fraser and Thomas Proft).
  • Wellcome Trust Sanger Institute (WTSI: Julian Parkhill, Matthew Holden, Stephen Bentley, David Goulding)
  • University of Cambridge (Sharon Peacock)

Selected Publications

Journal Articles

Lynskey NN, Banerji S, Johnson LA, et al., 2015, Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction, PLOS Pathogens, Vol:11, ISSN:1553-7366

Moore LS, Leslie A, Meltzer M, et al., 2015, Corynebacterium ulcerans cutaneous diphtheria., The Lancet Infectious Diseases, Vol:15, ISSN:1474-4457, Pages:1100-1107

Turner CE, Abbott J, Lamagni T, et al., 2015, Emergence of a New Highly Successful Acapsular Group A Streptococcus Clade of Genotype emm89 in the United Kingdom, MBIO, Vol:6, ISSN:2150-7511

Lamb LEM, Sriskandan S, Tan LKK, 2015, Bromine, bear-claw scratch fasciotomies, and the Eagle effect: management of group A streptococcal necrotising fasciitis and its association with trauma, Lancet Infectious Diseases, Vol:15, ISSN:1473-3099, Pages:109-121

Lynskey NN, Goulding D, Gierula M, et al., 2013, RocA Truncation Underpins Hyper-Encapsulation, Carriage Longevity and Transmissibility of Serotype M18 Group A Streptococci, PLOS Pathogens, Vol:9, ISSN:1553-7366

More Publications