Publications
216 results found
Belcher E, Evans TW, Sriskandan S, et al., 2003, Escherichia coli induces nitric oxide release in cardiovascular tissue via a toll like receptor 4-independent pathway, Meeting of the British-Pharmacological-Society-Clinical-Pharmacology-Section, Publisher: WILEY, Pages: U16-U16, ISSN: 0007-1188
Belcher E, Evans TW, Sriskandan S, et al., 2003, Gram-positive <i>Staphylococcus aureus</i> contrasts with Gram-negative <i>Escherichia coli</i> in the induction of tumour necrosis factor-alpha and nitric oxide from macrophages in urine, Meeting of the Intensive-Care-Society, Publisher: OXFORD UNIV PRESS, Pages: 540P-541P, ISSN: 0007-0912
- Author Web Link
- Cite
- Citations: 2
Desai PR, Sriskandan S, 2003, Hypothermia in a child secondary to ibuprofen [2], Archives of Disease in Childhood, Vol: 88, Pages: 87-88, ISSN: 0003-9888
- Cite
- Citations: 11
Fenwick P, Ryan C, Sriskandan S, et al., 2003, Application of a rat model of streptococcal shock to evaluate on-line hemoperfusion and removal of circulating superantigens, CRITICAL CARE MEDICINE, Vol: 31, Pages: 171-178, ISSN: 0090-3493
- Author Web Link
- Cite
- Citations: 13
Hopkins P, Sriskandan S, 2002, Gram-positive bacterial infection in severe sepsis, Clinical Intensive Care, Vol: 13, Pages: 147-160, ISSN: 0956-3075
- Cite
- Citations: 2
Belcher E, Evans TW, Sriskandan S, et al., 2002, The main site of iNOS activity induced by Gram postive <i>Staphylococcus aureus</i> may be blood vessels and not macrophages:: Comparisons with Gram negative <i>Escherichia coli</i>, Winter Meeting of the British-Thoracic-Society, Publisher: BRITISH MED JOURNAL PUBL GROUP, ISSN: 0040-6376
Unnikrishnan M, Altmann DM, Proft T, et al., 2002, The bacterial superantigen streptococcal mitogenic exotoxin Z is the major immunoactive agent of <i>Streptococcus pyogenes</i>, JOURNAL OF IMMUNOLOGY, Vol: 169, Pages: 2561-2569, ISSN: 0022-1767
- Author Web Link
- Cite
- Citations: 69
Ferguson M, Edwards R, Finney SJ, et al., 2002, Proteolytic cleavage of human interleukin-8 by invasive Group A Streptococcal strains abrogates chemokine activity and recruitment of immune response, 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
Unnikrishnan M, Cohen J, Sriskandan S, 2001, Complementation of a <i>speA</i> negative <i>Streptococcus pyogenes</i> with <i>speA</i> -: effects on virulence and production of streptococcal pyrogenic exotoxin A, MICROBIAL PATHOGENESIS, Vol: 31, Pages: 109-114, ISSN: 0882-4010
- Author Web Link
- Cite
- Citations: 13
Sriskandan S, Unnikrishnan M, Krausz T, et al., 2001, Enhanced susceptibility to superantigen-associated streptococcal sepsis in human leukocyte antigen-DQ transgenic mice, JOURNAL OF INFECTIOUS DISEASES, Vol: 184, Pages: 166-173, ISSN: 0022-1899
- Author Web Link
- Cite
- Citations: 61
Sriskandan S, Kemball-Cook G, Moyes D, et al., 2000, Contact activation in shock caused by invasive group A <i>Streptococcus pyogenes</i>, CRITICAL CARE MEDICINE, Vol: 28, Pages: 3684-3691, ISSN: 0090-3493
- Author Web Link
- Cite
- Citations: 30
Sriskandan S, Unnikrishnan M, Krausz T, et al., 2000, Mitogenic factor (MF) is the major DNase of serotype M89 <i>Streptococcus pyogenes</i>, MICROBIOLOGY-SGM, Vol: 146, Pages: 2785-2792, ISSN: 1350-0872
- Author Web Link
- Cite
- Citations: 43
Sriskandan S, Cohen J, 2000, Kallikrein-kinin system activation in streptococcal toxic shock syndrome, CLINICAL INFECTIOUS DISEASES, Vol: 30, Pages: 961-962, ISSN: 1058-4838
- Author Web Link
- Cite
- Citations: 21
Sriskandan S, 2000, Assay for superantigens., Methods Mol Med, Vol: 36, Pages: 67-79, ISSN: 1543-1894
This chapter describes a quantitative assay for the streptococcal superantigen, streptococcal pyrogenic exotoxin A (SPEA), which can be used in broth, tissue-culture media, and certain sera. The protocol can be adapted to allow measurement of any bacterial superantigen or protein toxin, using different oligonucleotides to amplify the coding sequences from bacterial DNA. Previously, measurement of bacterial toxins such as SPEA was limited by poor test sensitivity and test samples could only be analyzed if concentrated. Techniques included Ouchterlony immunodiffusion or enzyme-linked immuno-sorbent assay (ELISA), although the lower limit of detection was 100-fold greater than that achievable in this system. (1-3) Recent methods described have achieved improved sensitivities, some using sandwich ELISA techniques, others using competitive ELISA techniques. (4-8).
Unnikrishnan M, Cohen J, Sriskandan S, 1999, Growth-phase-dependent expression of virulence factors in an M1T1 clinical isolate of <i>Streptococcus pyogenes</i>, INFECTION AND IMMUNITY, Vol: 67, Pages: 5495-5499, ISSN: 0019-9567
- Author Web Link
- Cite
- Citations: 53
Sriskandan S, Unnikrishnan M, Krausz T, et al., 1999, Molecular analysis of the role of streptococcal pyrogenic exotoxin A (SPEA) in invasive soft-tissue infection resulting from <i>Streptococcus pyogenes</i>, MOLECULAR MICROBIOLOGY, Vol: 33, Pages: 778-790, ISSN: 0950-382X
- Author Web Link
- Cite
- Citations: 38
Sriskandan S, Cohen J, 1999, Gram-positive sepsis - Mechanisms and differences from gram-negative sepsis, INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, Vol: 13, Pages: 397-+, ISSN: 0891-5520
- Author Web Link
- Cite
- Citations: 121
Sriskandan S, Kemball-Cook G, Moyes D, et al., 1999, Coagulation abnormalities in severe streptococcal shock syndrome, SHOCK, Vol: 12, Pages: 21-22, ISSN: 1073-2322
Sriskandan S, Moves D, Cohen J, 1998, Previous exposure to superantigen enhances host inflammatory responses and susceptibility to infection with SPEA-producing Streptococcus pyogenes, International Congress and Symposium Series - Royal Society of Medicine, ISSN: 0142-2367
Sriskandan S, McKee A, Hall L, et al., 1997, Comparative effects of clindamycin and ampicillin on superantigenic activity of Streptococcus pyogenes, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 40, Pages: 275-277, ISSN: 0305-7453
- Author Web Link
- Cite
- Citations: 52
Curtis N, Jacobs M, Sriskandan S, 1997, Musculoskeletal side-effects of varicella, LANCET, Vol: 349, Pages: 1623-1624, ISSN: 0140-6736
- Author Web Link
- Cite
- Citations: 2
Sriskandan S, Moyes D, Buttery LK, et al., 1997, The role of nitric oxide in experimental murine sepsis due to pyrogenic exotoxin A-producing Streptococcus pyogenes, INFECTION AND IMMUNITY, Vol: 65, Pages: 1767-1772, ISSN: 0019-9567
- Author Web Link
- Cite
- Citations: 24
Jones HA, Sriskandan S, Peters AM, et al., 1997, Dissociation of neutrophil emigration and metabolic activity in lobar pneumonia and bronchiectasis, EUROPEAN RESPIRATORY JOURNAL, Vol: 10, Pages: 795-803, ISSN: 0903-1936
- Author Web Link
- Cite
- Citations: 110
Feng Q, Rahman SU, Rhodes CG, et al., 1997, Pulmonary and cardiac beta-adrenoceptor density in vivo in asthmatic subjects, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 155, Pages: 1130-1134, ISSN: 1073-449X
- Author Web Link
- Cite
- Citations: 13
Sriskandan S, Moyes D, Lemm G, et al., 1996, Lymphotoxin-alpha (TNF-beta) during sepsis, CYTOKINE, Vol: 8, Pages: 933-937, ISSN: 1043-4666
- Author Web Link
- Cite
- Citations: 11
Sriskandan S, Moyes D, Cohen J, 1996, Detection of circulating bacterial superantigen and lymphotoxin-alpha in patients with streptococcal toxic-shock syndrome, LANCET, Vol: 348, Pages: 1315-1316, ISSN: 0140-6736
- Author Web Link
- Cite
- Citations: 50
Hayes MJ, Qing F, Rhodes CG, et al., 1996, In vivo quantification of human pulmonary beta-adrenoceptors: Effect of beta-agonist therapy, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 154, Pages: 1277-1283, ISSN: 1073-449X
- Author Web Link
- Cite
- Citations: 46
Sriskandan S, Moyes D, Buttery LK, et al., 1996, Streptococcal pyrogenic exotoxin a release, distribution, and role in a murine model of fasciitis and multiorgan failure due to Streptococcus pyogenes, JOURNAL OF INFECTIOUS DISEASES, Vol: 173, Pages: 1399-1407, ISSN: 0022-1899
- Author Web Link
- Cite
- Citations: 50
Sriskandan S, Evans TJ, Cohen J, 1996, Bacterial superantigen-induced human lymphocyte responses are nitric oxide dependent and mediated by IL-12 and IFN-gamma, JOURNAL OF IMMUNOLOGY, Vol: 156, Pages: 2430-2435, ISSN: 0022-1767
- Author Web Link
- Cite
- Citations: 56
Sriskandan S, Labrecque LG, Schofield J, 1996, Diffuse pneumonia associated with infectious mononucleosis: Detection of Epstein-Barr virus in lung tissue by in situ hybridization, CLINICAL INFECTIOUS DISEASES, Vol: 22, Pages: 578-579, ISSN: 1058-4838
- Author Web Link
- Cite
- Citations: 12
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.