Imperial College London
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ProfessorShiraneeSriskandan

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases
 
 
 
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Contact

 

s.sriskandan

 
 
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Assistant

 

Ms Teyanna Gaeta +44 (0)20 3313 1943

 
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Location

 

8N21ACWBCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Blandy:2019:10.1016/j.jhin.2018.10.024,
author = {Blandy, O and Honeyford, K and Gharbi, M and Thomas, A and Ramzan, F and Ellington, MJ and Hope, R and Holmes, A and Johnson, AP and Aylin, P and Woodford, N and Sriskandan, S},
doi = {10.1016/j.jhin.2018.10.024},
journal = {Journal of Hospital Infection},
pages = {120--128},
title = {Factors that impact on the burden of Escherichia coli bacteraemia: multivariable regression analysis of 2011-2015 data from West London},
url = {http://dx.doi.org/10.1016/j.jhin.2018.10.024},
volume = {101},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe incidence of Escherichia coli bacteraemia in England is increasing amid concern regarding the roles of antimicrobial resistance and nosocomial acquisition on burden of disease.AimTo determine the relative contributions of hospital-onset E. coli blood stream infection and specific E. coli antimicrobial resistance patterns to the burden and severity of E. coli bacteremia in West London.MethodsPatient and antimicrobial susceptibility data were collected for all cases of E. coli bacteraemia between 2011 and 2015. Multivariable logistic regression was used to determine the association between the category of infection (hospital or community-onset) and length of stay, intensive care unit admission, and 30-day all-cause mortality.FindingsE. coli bacteraemia incidence increased by 76% during the study period, predominantly due to community-onset cases. Resistance to quinolones, third-generation cephalosporins, and aminoglycosides also increased over the study period, occurring in both community- and hospital-onset cases. Hospital-onset and non-susceptibility to either quinolones or third-generation cephalosporins were significant risk factors for prolonged length of stay, as was older age. Rates of mortality were 7% and 12% at 7 and 30 days, respectively. Older age, a higher comorbidity score, and bacteraemia caused by strains resistant to three antibiotic classes were all significant risk factors for mortality at 30 days.ConclusionMultidrug resistance, increased age, and comorbidities were the main drivers of adverse outcome. The rise in E. coli bacteraemia was predominantly driven by community-onset infections, and initiatives to prevent community-onset cases should be a major focus to reduce the quantitative burden of E. coli infection.
AU  - Blandy,O
AU  - Honeyford,K
AU  - Gharbi,M
AU  - Thomas,A
AU  - Ramzan,F
AU  - Ellington,MJ
AU  - Hope,R
AU  - Holmes,A
AU  - Johnson,AP
AU  - Aylin,P
AU  - Woodford,N
AU  - Sriskandan,S
DO  - 10.1016/j.jhin.2018.10.024
EP  - 128
PY  - 2019///
SN  - 0195-6701
SP  - 120
TI  - Factors that impact on the burden of Escherichia coli bacteraemia: multivariable regression analysis of 2011-2015 data from West London
T2  - Journal of Hospital Infection
UR  - http://dx.doi.org/10.1016/j.jhin.2018.10.024
UR  - http://hdl.handle.net/10044/1/65964
VL  - 101
ER  -
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