Imperial College London
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ProfessorShiraneeSriskandan

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases
 
 
 
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Contact

 

s.sriskandan

 
 
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Assistant

 

Ms Teyanna Gaeta +44 (0)20 3313 1943

 
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Location

 

8N21ACWBCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tan:2021:10.1038/s41541-021-00326-3,
author = {Tan, LKK and Reglinski, M and Teo, D and Reza, N and Lamb, LEM and Nageshwaran, V and Turner, CE and Wikstrom, M and Frick, I-M and Bjorck, L and Sriskandan, S},
doi = {10.1038/s41541-021-00326-3},
journal = {npj Vaccines},
pages = {1--9},
title = {Vaccine-induced, but not natural immunity, against the Streptococcal Inhibitor of complement protects against invasive disease},
url = {http://dx.doi.org/10.1038/s41541-021-00326-3},
volume = {6},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Highly pathogenic emm1 Streptococcus pyogenes strains secrete the multidomain Streptococcal inhibitor of complement (SIC) that binds and inactivates components of the innate immune response. We aimed to determine if naturally occurring or vaccine-induced antibodies to SIC are protective against invasive S. pyogenes infection. Immunisation with full-length SIC protected mice against systemic bacterial dissemination following intranasal or intramuscular infection with emm1 S. pyogenes. Vaccine-induced rabbit anti-SIC antibodies, but not naturally occurring human anti-SIC antibodies, enhanced bacterial clearance in an ex vivo whole-blood assay. SIC vaccination of both mice and rabbits resulted in antibody recognition of all domains of SIC, whereas naturally occurring human anti-SIC antibodies recognised the proline-rich region of SIC only. We, therefore, propose a model whereby natural infection with S. pyogenes generates non-protective antibodies against the proline-rich region of SIC, while vaccination with full-length SIC permits the development of protective antibodies against all SIC domains.
AU  - Tan,LKK
AU  - Reglinski,M
AU  - Teo,D
AU  - Reza,N
AU  - Lamb,LEM
AU  - Nageshwaran,V
AU  - Turner,CE
AU  - Wikstrom,M
AU  - Frick,I-M
AU  - Bjorck,L
AU  - Sriskandan,S
DO  - 10.1038/s41541-021-00326-3
EP  - 9
PY  - 2021///
SN  - 2059-0105
SP  - 1
TI  - Vaccine-induced, but not natural immunity, against the Streptococcal Inhibitor of complement protects against invasive disease
T2  - npj Vaccines
UR  - http://dx.doi.org/10.1038/s41541-021-00326-3
UR  - https://www.nature.com/articles/s41541-021-00326-3
UR  - http://hdl.handle.net/10044/1/89060
VL  - 6
ER  -
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