Imperial College London
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ProfessorShiraneeSriskandan

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases
 
 
 
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Contact

 

s.sriskandan

 
 
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Assistant

 

Ms Teyanna Gaeta +44 (0)20 3313 1943

 
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Location

 

8N21ACWBCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@misc{Parks:2019:10.1101/19003087,
author = {Parks, T and Auckland, K and Lamagni, T and Mentzer, A and Elliott, K and Guy, R and Cartledge, D and Strakova, L and OConnor, D and Pollard, A and Chapman, S and Thomas, M and Brodlie, M and Colot, J and DOrtenzio, E and Baroux, N and Mirabel, M and Gilchrist, J and Scott, A and Williams, T and Knight, J and Steer, A and Hill, A and Sriskandan, S},
doi = {10.1101/19003087},
title = {Host genetic variants near the <i>PAX5</i> gene locus associate with susceptibility to invasive group A streptococcal disease},
type = {Other},
url = {http://dx.doi.org/10.1101/19003087},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - GEN
AB  - We undertook a genome-wide association study of susceptibility to invasive group A streptococcal (GAS) disease combining data from distinct clinical manifestations and ancestral populations. Amongst other signals, we identified a susceptibility locus located 18kb from PAX5 , an essential B-cell gene, which conferred a nearly two-fold increased risk of disease (rs1176842, odds ratio 1.8, 95% confidence intervals 1.5-2.3, P=3.2×10 −7 ). While further studies are needed, this locus could plausibly explain some inter-individual differences in antibody-mediated immunity to GAS, perhaps providing insight into the effects of intravenous immunoglobulin in streptococcal toxic shock.
AU  - Parks,T
AU  - Auckland,K
AU  - Lamagni,T
AU  - Mentzer,A
AU  - Elliott,K
AU  - Guy,R
AU  - Cartledge,D
AU  - Strakova,L
AU  - OConnor,D
AU  - Pollard,A
AU  - Chapman,S
AU  - Thomas,M
AU  - Brodlie,M
AU  - Colot,J
AU  - DOrtenzio,E
AU  - Baroux,N
AU  - Mirabel,M
AU  - Gilchrist,J
AU  - Scott,A
AU  - Williams,T
AU  - Knight,J
AU  - Steer,A
AU  - Hill,A
AU  - Sriskandan,S
DO  - 10.1101/19003087
PY  - 2019///
TI  - Host genetic variants near the <i>PAX5</i> gene locus associate with susceptibility to invasive group A streptococcal disease
UR  - http://dx.doi.org/10.1101/19003087
ER  -
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