Imperial College London
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ProfessorShiraneeSriskandan

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases
 
 
 
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Contact

 

s.sriskandan

 
 
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Assistant

 

Ms Teyanna Gaeta +44 (0)20 3313 1943

 
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Location

 

8N21ACWBCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jauneikaite:2021:10.1101/2021.06.03.21257959,
author = {Jauneikaite, E and Pichon, B and Mosavie, M and Fallowfield, JL and Davey, T and Thorpe, N and Nelstrop, A and Sriskandan, S and Lamb, LE},
doi = {10.1101/2021.06.03.21257959},
title = {Characterisation of <i>Staphylococcus argenteus</i> carried by healthy Royal Marines: a molecular epidemiology case-study},
url = {http://dx.doi.org/10.1101/2021.06.03.21257959},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Objectives</jats:title><jats:p>During a prospective study of <jats:italic>S. aureus</jats:italic> carriage in Royal Marines (RM) recruits, six <jats:italic>S. argenteus</jats:italic> strains were identified in four recruits undertaking military training together. As <jats:italic>S. argenteus</jats:italic> sepsis leads to mortality similar to <jats:italic>S. aureus</jats:italic>, we determined the potential for person-to-person transmission, to evaluate future outbreak risk.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We used whole-genome sequencing to characterise <jats:italic>S. argenteus</jats:italic> and investigate phylogenetic relationships between isolates. Participant colonisation with <jats:italic>S. aureus</jats:italic> and skin and soft tissue infection acquisition were recorded.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>All six <jats:italic>S. argenteus</jats:italic> strains were <jats:italic>spa</jats:italic>-type t5078, ST2250. Strains were detected in 4/40 recruits in the same troop (training cohort) in weeks 1, 6 or 15 of training. No <jats:italic>mec, tsst</jats:italic> or <jats:italic>LukPV</jats:italic> genes were detected. We identified differences of 10-35 core SNPs between <jats:italic>S. argenteus</jats:italic> from different recruits. In two recruits, two <jats:italic>S. argenteus</jats:italic> strains were isolated; these could be distinguished by 3 and 15 core SNPs in each case. <jats:italic>S. argenteus</jats:italic> was not identified in any one of the other 21 participating troops (1,012 recruits).</jats:p></jats:sec><jats:sec><jats:title>Conclusions&
AU  - Jauneikaite,E
AU  - Pichon,B
AU  - Mosavie,M
AU  - Fallowfield,JL
AU  - Davey,T
AU  - Thorpe,N
AU  - Nelstrop,A
AU  - Sriskandan,S
AU  - Lamb,LE
DO  - 10.1101/2021.06.03.21257959
PY  - 2021///
TI  - Characterisation of <i>Staphylococcus argenteus</i> carried by healthy Royal Marines: a molecular epidemiology case-study
UR  - http://dx.doi.org/10.1101/2021.06.03.21257959
ER  -
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