Imperial College London
Alternate

ProfessorSudhinThayyil

Faculty of Medicine, Department of Brain Sciences

Professor of Perinatal Neuroscience
 
 
 
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Contact

 

+44 (0)20 3313 8515s.thayyil

 
 
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Location

 

529Hammersmith HouseHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ivain:2021:10.1038/s41372-021-01132-4,
author = {Ivain, P and Montaldo, P and Khan, A and Elagovan, R and Burgod, C and Moreno, Morales M and Pant, S and Thayyil, S and Ivain, P and Montaldo, P and Khan, A and Elagovan, R and Burgod, C and Moreno-Morales, M and Pant, S and Thayyil, S},
doi = {10.1038/s41372-021-01132-4},
journal = {Journal of Perinatology},
pages = {2134--2140},
title = {Erythropoietin monotherapy for neuroprotection after neonatal encephalopathy in low 2 to-middle income countries: A systematic review and meta-analysis},
url = {http://dx.doi.org/10.1038/s41372-021-01132-4},
volume = {41},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective: We examined whether erythropoietin monotherapy improves neurodevelopmental outcomes in near-term and term infants with neonatal encephalopathy (NE) in low-middle income countries (LMICs). Methods: We searched Pubmed, Embase, and Web of Science databases to identify studies that used erythropoietin (1,500 to 12,500 units/kg/dose) or a derivative to treat NE. Results: Five studies, with a total of 348 infants in LMICs, were retrieved. However, only three of the five studies met the primary outcome of death or neuro-disability at 18 months of age or later. Erythropoietin reduced the risk of death (during neonatal period and at follow55 up) or neuro-disability at 18 months or later (p<0.05). Death or neuro-disability occurred in 27.6% of the erythropoietin group and 49.7% of the comparison group (Risk Ratio 0.56 (95% CI: 0.42 to 0.75). Conclusion: The pooled data suggests that erythropoietin monotherapy may improve outcomes after NE in LMICs where therapeutic hypothermia is not available.
AU  - Ivain,P
AU  - Montaldo,P
AU  - Khan,A
AU  - Elagovan,R
AU  - Burgod,C
AU  - Moreno,Morales M
AU  - Pant,S
AU  - Thayyil,S
AU  - Ivain,P
AU  - Montaldo,P
AU  - Khan,A
AU  - Elagovan,R
AU  - Burgod,C
AU  - Moreno-Morales,M
AU  - Pant,S
AU  - Thayyil,S
DO  - 10.1038/s41372-021-01132-4
EP  - 2140
PY  - 2021///
SN  - 0743-8346
SP  - 2134
TI  - Erythropoietin monotherapy for neuroprotection after neonatal encephalopathy in low 2 to-middle income countries: A systematic review and meta-analysis
T2  - Journal of Perinatology
UR  - http://dx.doi.org/10.1038/s41372-021-01132-4
UR  - https://www.nature.com/articles/s41372-021-01132-4
UR  - http://hdl.handle.net/10044/1/88150
VL  - 41
ER  -
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