Imperial College London
Alternate

ProfessorSudhinThayyil

Faculty of Medicine, Department of Brain Sciences

Professor of Perinatal Neuroscience
 
 
 
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Contact

 

+44 (0)20 3313 8515s.thayyil

 
 
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Location

 

529Hammersmith HouseHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Moreno:2021:10.1136/archdischild-2020-321164,
author = {Moreno, Morales M and Montaldo, P and Ivain, P and Pant, S and Kumar, V and Krishnan, V and Shankaran, S and Thayyil, S},
doi = {10.1136/archdischild-2020-321164},
journal = {Archives of Disease in Childhood: Fetal and Neonatal Edition},
pages = {669--672},
title = {Association of Total Sarnat Score with brain injury and neurodevelopmental outcomes after neonatal encephalopathy},
url = {http://dx.doi.org/10.1136/archdischild-2020-321164},
volume = {106},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We examined the association of Total Sarnat Score (TSS) with brain injury on neonatal magnetic resonance (MR) and adverse neurodevelopmental outcome (NDO) (death or moderate or severe disability) at 2 years of age in 145 infants undergoing therapeutic hypothermia for neonatal encephalopathy. TSS was associated with basal ganglia/thalamic injury on conventional MR (p=0.03) and thalamic N-acetyl aspartate on MR spectroscopy (R2=0.16, p=0.004) at 2 weeks of age, and Bayley Composite Cognitive (R2=0.18, p=0.01), Motor (R2=0.15, p=0.02) and Language (R2=0.11, p=0.01) Scores at 2 years of age after adjustment for seizures at the time of neurological assessment. The accuracy of TSS (area under the curve (AUC)=0.71) for predicting adverse NDO was similar to the modified Sarnat staging (AUC=0.72). TSS of >12 within 6 hours of birth indicated high risk of adverse NDO, while TSS of <4 indicated intact survival and was reassuring of a good outcome among cooled infants.
AU  - Moreno,Morales M
AU  - Montaldo,P
AU  - Ivain,P
AU  - Pant,S
AU  - Kumar,V
AU  - Krishnan,V
AU  - Shankaran,S
AU  - Thayyil,S
DO  - 10.1136/archdischild-2020-321164
EP  - 672
PY  - 2021///
SN  - 1359-2998
SP  - 669
TI  - Association of Total Sarnat Score with brain injury and neurodevelopmental outcomes after neonatal encephalopathy
T2  - Archives of Disease in Childhood: Fetal and Neonatal Edition
UR  - http://dx.doi.org/10.1136/archdischild-2020-321164
UR  - http://hdl.handle.net/10044/1/89347
VL  - 106
ER  -
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