Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Clinical Professor of Cardiovascular Pharmacology



+44 (0)20 7594 1101s.thom




Miss Paula Burak +44 (0)20 3313 7357




330ICTEM buildingHammersmith Campus





Simon Thom is Professor of Cardiovascular Medicine and Pharmacology at the National Heart and Lung Institute, Imperial College London.  He is a Consultant Physician at St Mary’s Hospital, Paddington and Co-director of the Peart-Rose Cardiovascular Disease Prevention Clinic based in the International Centre for Circulatory Health.  He is also co-director of the NW London Diabetes Research Network – part of the UK national Clinical Research Network.

He trained at St Mary’s Medical School and subsequently in Bath, Newcastle-upon-Tyne and London.  He is a Fellow of the Royal College of Physicians, holds an MD from the University of London and was recently a member of the Executive Committee of the British Hypertension Society and the national hypertension guidelines group.

His clinical interests include general medicine, hypertension, cardiovascular disease prevention and hypertensive complications in pregnancy.  Research interests include vascular pharmacology and physiology, structure and mechanics of the circulation and haemodynamics in relation to vascular disease.  He leads clinical trials of cardiovascular treatments – currently the multi-centered UMPIRE trial evaluating a “cardiovascular polypill” that includes collaborators and participants in India, Australia, the Netherlands, Ireland and UK. 

Research support comes from the British Heart Foundation, the Wellcome Trust, the European Commission, the Engineering & Physical Sciences Research Council (EPSRC) and the pharmaceutical industry.


Selected Publications

Journal Articles

Manisty C, Mayet J, Tapp RJ, et al., 2010, Wave Reflection Predicts Cardiovascular Events in Hypertensive Individuals Independent of Blood Pressure and Other Cardiovascular Risk Factors An ASCOT (Anglo-Scandinavian Cardiac Outcome Trial) Substudy, Journal of the American College of Cardiology, Vol:56, ISSN:0735-1097, Pages:24-30

Thom S, Stettler C, Stanton A, et al., 2009, Differential Effects of Antihypertensive Treatment on the Retinal Microcirculation An Anglo-Scandinavian Cardiac Outcomes Trial Substudy, Hypertension, Vol:54, ISSN:0194-911X, Pages:405-408

Torii R, Wood NB, Hadjiloizou N, et al., 2009, Stress phase angle depicts differences in coronary artery hemodynamics due to changes in flow and geometry after percutaneous coronary intervention, American Journal of Physiology - Heart and Circulatory Physiology, Vol:296, ISSN:0363-6135, Pages:H765-H776

Williams B, Lacy PS, Cruickshank JK, et al., 2009, Impact of Statin Therapy on Central Aortic Pressures and Hemodynamics Principal Results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study, Circulation, Vol:119, ISSN:0009-7322, Pages:53-U98

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