Imperial College London
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Professor Sharon Marie Weldon

Faculty of Medicine, Department of Surgery & Cancer

Honorary Research Fellow
 
 
 
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Contact

 

s.weldon Website

 
 
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Location

 

H3/08Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Thompson:2020:10.1186/s13643-020-01398-3,
author = {Thompson, T and Dias, S and Poulter, D and Weldon, S and Marsh, L and Rossato, C and Shin, JI and Firth, J and Veronese, N and Dragioti, E and Stubbs, B and Solmi, M and Maher, CG and Cipriani, A and Ioannidis, JPA},
doi = {10.1186/s13643-020-01398-3},
journal = {Syst Rev},
title = {Efficacy and acceptability of pharmacological and non-pharmacological interventions for non-specific chronic low back pain: a protocol for a systematic review and network meta-analysis.},
url = {http://dx.doi.org/10.1186/s13643-020-01398-3},
volume = {9},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Despite the enormous financial and humanistic burden of chronic low back pain (CLBP), there is little consensus on what constitutes the best treatment options from a multitude of competing interventions. The objective of this network meta-analysis (NMA) is to determine the relative efficacy and acceptability of primary care treatments for non-specific CLBP, with the overarching aim of providing a comprehensive evidence base for informing treatment decisions. METHODS: We will perform a systematic search to identify randomised controlled trials of interventions endorsed in primary care guidelines for the treatment of non-specific CLBP in adults. Information sources searched will include major bibliographic databases (MEDLINE, Embase, CENTRAL, CINAHL, PsycINFO and LILACS) and clinical trial registries. Our primary outcomes will be patient-reported pain ratings and treatment acceptability (all-cause discontinuation), and secondary outcomes will be functional ability, quality of life and patient/physician ratings of overall improvement. A hierarchical Bayesian class-based NMA will be performed to determine the relative effects of different classes of pharmacological (NSAIDs, opioids, paracetamol, anti-depressants, muscle relaxants) and non-pharmacological (exercise, patient education, manual therapies, psychological therapy, multidisciplinary approaches, massage, acupuncture, mindfulness) interventions and individual treatments within a class (e.g. NSAIDs: diclofenac, ibuprofen, naproxen). We will conduct risk of bias assessments and threshold analysis to assess the robustness of the findings to potential bias. We will compute the effect of different interventions relative to placebo/no treatment for both short- and long-term efficacy and acceptability. DISCUSSION: While many factors are important in selecting an appropriate intervention for an individual patient, evidence for the analgesic effects and acceptability of a treatment are key factors in guiding t
AU  - Thompson,T
AU  - Dias,S
AU  - Poulter,D
AU  - Weldon,S
AU  - Marsh,L
AU  - Rossato,C
AU  - Shin,JI
AU  - Firth,J
AU  - Veronese,N
AU  - Dragioti,E
AU  - Stubbs,B
AU  - Solmi,M
AU  - Maher,CG
AU  - Cipriani,A
AU  - Ioannidis,JPA
DO  - 10.1186/s13643-020-01398-3
PY  - 2020///
TI  - Efficacy and acceptability of pharmacological and non-pharmacological interventions for non-specific chronic low back pain: a protocol for a systematic review and network meta-analysis.
T2  - Syst Rev
UR  - http://dx.doi.org/10.1186/s13643-020-01398-3
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32503666
VL  - 9
ER  -
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