Imperial College London


Faculty of MedicineDepartment of Medicine

Honorary Clinical Research Fellow







Commonwealth BuildingHammersmith Campus





Sophie is a Consultant Physician in Infectious Diseases and General Medicine. She is currently based in Singapore, with appointments at Singapore-MIT alliance for research and technology (SMART) and at DUKE-NUS as an Adjunct Assistant Professor. She also holds an honorary Consultant appointment at London North West Healthcare NHS Trust in the UK.

She was awarded a PhD in 2016, through the Imperial College Wellcome Trust Clinical PhD Programme, on microvascular and endothelial dysfunction in dengue, based at the Oxford University Clinical Research Unit-Vietnam.

She studied medicine at the University of Southampton in the UK, and undertook a Masters degree at the London School of Hygiene and Tropical Medicine. She is a member of the Royal College of Physicians in London. She has clinical academic experience in variety of tropical diseases, including Chagas disease, malaria and dengue, having worked in northern Australia, Kenya, Tanzania and Honduras. Her work has been supported by grants from the Wellcome Trust, British Heart Foundation and the Royal Society of Tropical Medicine.

Her current research interests are in the pathophysiology of severe dengue infections and clinical trials of novel therapeutics.




Yacoub S, Lam PK, Huynh TT, et al., 2017, Endothelial nitric oxide pathways in the pathophysiology of dengue: a prospective observational study., Clin Infect Dis

Yacoub S, Trieu HT, Phung KL, et al., 2017, Cardio-haemodynamic assessment and venous lactate in severe dengue: Relationship with recurrent shock and respiratory distress, Plos Neglected Tropical Diseases, Vol:11, ISSN:1935-2735

Jaenisch T, Dong THT, Nguyen TTK, et al., 2016, Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries, Bmc Infectious Diseases, Vol:16, ISSN:1471-2334

Nguyen VVC, Le BC, Desquesnes M, et al., 2016, A Clinical and Epidemiological Investigation of the First Reported Human Infection With the Zoonotic Parasite Trypanosoma evansi in Southeast Asia, Clinical Infectious Diseases, Vol:62, ISSN:1058-4838, Pages:1002-1008

Yacoub S, Mongkolsapaya J, Screaton G, 2016, Recent advances in understanding dengue., F1000res, Vol:5, ISSN:2046-1402

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