Imperial College London


Faculty of MedicineDepartment of Infectious Disease

Honorary Clinical Research Fellow







Commonwealth BuildingHammersmith Campus





Sophie is a Consultant Physician in Infectious Diseases and General Medicine and is the Dengue Research Group Head at the Oxford University Clinical Research Unit (OUCRU), based in Ho Chi Minh City, Vietnam. She is as an Adjunct Assistant Professor at the Lee Kong Chian School of Medicine in Singapore, and holds an honorary Consultant appointment at London North West University Healthcare NHS Trust in the UK.

She was awarded a PhD in 2016, through the Imperial College Wellcome Trust Clinical PhD Programme and has a Masters degree from the London School of Hygiene and Tropical Medicine. She is a member of the Royal College of Physicians in London. She has clinical academic experience in a variety of tropical diseases, including Chagas disease, malaria and dengue, having worked in northern Australia, Kenya, Tanzania and Honduras. Her work has been supported by grants from the Wellcome Trust, NMRC Singapore, the WHO, British Heart Foundation and the Royal Society of Tropical Medicine.

She currently leads a translational programme of dengue research in OUCRU-Vietnam, including pathogenesis studies, innovative technology for monitoring critically ill patients, physiology studies of severe dengue infections as well as clinical trials of novel therapeutics.




Rodriguez-Manzano J, Ying Chia P, Wen Yeo T, et al., 2018, Improving Dengue diagnostics and management through innovative technology, Current Infectious Disease Reports, Vol:20, ISSN:1534-3146

Morra ME, Altibi AMA, Iqtadar S, et al., 2018, Definitions for warning signs and signs of severe dengue according to the WHO 2009 classification: Systematic review of literature, Reviews in Medical Virology, Vol:28, ISSN:1052-9276

Nguyen THM, Nguyen HP, Ho DTN, et al., 2018, Dengue-Associated Posterior Reversible Encephalopathy Syndrome, Vietnam, Emerging Infectious Diseases, Vol:24, ISSN:1080-6040, Pages:402-404

Yacoub S, Trieu HT, Phung KL, et al., 2017, Cardio-haemodynamic assessment and venous lactate in severe dengue: Relationship with recurrent shock and respiratory distress, Plos Neglected Tropical Diseases, Vol:11, ISSN:1935-2735

Yacoub S, Lam PK, Huynh TT, et al., 2017, Endothelial nitric oxide pathways in the pathophysiology of dengue: a prospective observational study., Clinical Infectious Diseases, Vol:65, ISSN:1058-4838, Pages:1453-1461

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