My group investigates why the aged brain is vulnerable to neurodegeneration and asks whether we can alleviate this susceptibility. We focus on the role of key homeostatic neural-circuit plasticity processes thought to be critical for healthy network function.
After graduating from Oxford University in 2006 I was awarded an MRC Capacity building Ph.D. studentship at King’s College London to investigate synaptic connection loss and neural plasticity in the cortex. I then completed a post-doc investigating how homeostatic plasticity regulates neural activity in the adult visual cortex at University College London. In October 2015, I won the Edmond J Safra Fellowship which supports early career researchers during their transition to independence. In April 2018 I was awarded a UK Dementia Research Institute Fellowship and became a lecturer in the Division of Brain Sciences at Imperial College London. Here, I use a combination of in vivo voltage and calcium imaging, bioelectronics and electrophysiology to investigate the neural-circuit plasticity factors that make the aged brain susceptible to neurodegeneration and ultimately dementia.
et al., 2019, Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex, Nature Communications, Vol:10, ISSN:2041-1723
et al., 2018, In vivo modeling of human neuron dynamics and Down syndrome, Science, Vol:362, ISSN:0036-8075
Barnes S, 2018, In vivo modelling of human neuron dynamics and Down syndrome, Science, ISSN:0036-8075
Sammons RP, Clopath C, Barnes SJ, 2018, Size-dependent axonal bouton dynamics following visual deprivation in vivo, Cell Reports, Vol:22, ISSN:2211-1247, Pages:576-584