Imperial College London
Dr Samuel Marguerat

DrSamuelMarguerat

Faculty of Natural Sciences, Department of Mathematics

Visiting Researcher
 
 
 
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Contact

 

+44 (0)20 3313 8331samuel.marguerat Website

 
 
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Location

 

5003CRB (Clinical Research Building)Hammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hocquet:2018:10.7554/eLife.38517,
author = {Hocquet, C and Robellet, X and Modolo, L and Sun, X-M and Burny, C and Cuylen-Haering, S and Toselli, E and Clauder-Muenster, S and Steinmetz, L and Haering, CH and Marguerat, S and Bernard, P},
doi = {10.7554/eLife.38517},
journal = {eLife},
title = {Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription},
url = {http://dx.doi.org/10.7554/eLife.38517},
volume = {7},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Condensins are genome organisers that shape chromosomes and promote theiraccurate transmission. Several studies have also implicated condensins in gene expression,although any mechanisms have remained enigmatic. Here, we report on the role of condensin ingene expression in fission and budding yeasts. In contrast to previous studies, we providecompelling evidence that condensin plays no direct role in the maintenance of the transcriptome,neither during interphase nor during mitosis. We further show that the changes in gene expressionin post-mitotic fission yeast cells that result from condensin inactivation are largely a consequenceof chromosome missegregation during anaphase, which notably depletes the RNA-exosome fromdaughter cells. Crucially, preventing karyotype abnormalities in daughter cells restores a normaltranscriptome despite condensin inactivation. Thus, chromosome instability, rather than a directrole of condensin in the transcription process, changes gene expression. This knowledge challengesthe concept of gene regulation by canonical condensin complexes.
AU  - Hocquet,C
AU  - Robellet,X
AU  - Modolo,L
AU  - Sun,X-M
AU  - Burny,C
AU  - Cuylen-Haering,S
AU  - Toselli,E
AU  - Clauder-Muenster,S
AU  - Steinmetz,L
AU  - Haering,CH
AU  - Marguerat,S
AU  - Bernard,P
DO  - 10.7554/eLife.38517
PY  - 2018///
SN  - 2050-084X
TI  - Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.38517
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446417500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/65015
VL  - 7
ER  -
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