Imperial College London
Dr Samuel Marguerat

DrSamuelMarguerat

Faculty of Natural Sciences, Department of Mathematics

Visiting Researcher
 
 
 
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Contact

 

+44 (0)20 3313 8331samuel.marguerat Website

 
 
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Location

 

5003CRB (Clinical Research Building)Hammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Keifenheim:2017:10.1016/j.cub.2017.04.016,
author = {Keifenheim, D and Sun, X-M and D'Souza, E and Ohira, MJ and Magner, M and Mayhew, MB and Marguerat, S and Rhind, N},
doi = {10.1016/j.cub.2017.04.016},
journal = {Current Biology},
pages = {1491--1497.e4},
title = {Size-Dependent Expression of the Mitotic Activator Cdc25 Suggests a Mechanism of Size Control in Fission Yeast},
url = {http://dx.doi.org/10.1016/j.cub.2017.04.016},
volume = {27},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Proper cell size is essential for cellular function. Nonetheless, despite more than 100 years of work on the subject, the mechanisms that maintain cell-size homeostasis are largely mysterious [ 1 ]. Cells in growing populations maintain cell size within a narrow range by coordinating growth and division. Bacterial and eukaryotic cells both demonstrate homeostatic size control, which maintains population-level variation in cell size within a certain range and returns the population average to that range if it is perturbed [ 1, 2 ]. Recent work has proposed two different strategies for size control: budding yeast has been proposed to use an inhibitor-dilution strategy to regulate size at the G1/S transition [ 3 ], whereas bacteria appear to use an adder strategy, in which a fixed amount of growth each generation causes cell size to converge on a stable average [ 4–6 ]. Here we present evidence that cell size in the fission yeast Schizosaccharomyces pombe is regulated by a third strategy: the size-dependent expression of the mitotic activator Cdc25. cdc25 transcript levels are regulated such that smaller cells express less Cdc25 and larger cells express more Cdc25, creating an increasing concentration of Cdc25 as cells grow and providing a mechanism for cells to trigger cell division when they reach a threshold concentration of Cdc25. Because regulation of mitotic entry by Cdc25 is well conserved, this mechanism may provide a widespread solution to the problem of size control in eukaryotes.
AU  - Keifenheim,D
AU  - Sun,X-M
AU  - D'Souza,E
AU  - Ohira,MJ
AU  - Magner,M
AU  - Mayhew,MB
AU  - Marguerat,S
AU  - Rhind,N
DO  - 10.1016/j.cub.2017.04.016
EP  - 1497
PY  - 2017///
SN  - 1879-0445
SP  - 1491
TI  - Size-Dependent Expression of the Mitotic Activator Cdc25 Suggests a Mechanism of Size Control in Fission Yeast
T2  - Current Biology
UR  - http://dx.doi.org/10.1016/j.cub.2017.04.016
UR  - http://hdl.handle.net/10044/1/53797
VL  - 27
ER  -
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