Imperial College London
Alternate

Shahid A Khan

Faculty of Medicine, Faculty of Medicine Centre

Professor of Practice (Hepatology)
 
 
 
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Contact

 

+44 (0)20 3312 6254shahid.khan

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Khuntikeo:2023:10.1007/978-3-031-35166-2_1,
author = {Khuntikeo, N and Andrews, RH and Petney, TN and Khan, SA},
booktitle = {Recent Results in Cancer Research},
doi = {10.1007/978-3-031-35166-2_1},
pages = {1--5},
title = {Introduction},
url = {http://dx.doi.org/10.1007/978-3-031-35166-2_1},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Cholangiocarcinoma (CCA) is a lethal cancer arising in the bile ducts within and just outside the liver. It occurs worldwide and falls into two etiologically defined groups, one related to chronic liver fluke infection and the other not. Liver fluke-related CCA is found in continental Southeast Asia (caused by Opisthorchis viverrini with infection leading to opisthorchiasis), East Asia (Clonorchis sinensis), and Eastern Europe and Russia (Opisthorchis felineus). Both O. viverrini and C. sinensis are classified as group one carcinogens, while recent data from O. felineus suggest the same. In Southeast Asia, an estimated 67.3 million peopleare at risk of O. viverrini infection and subsequently developing CCA. When the three liver fluke species are considered, an estimated 700 million people are at risk of infection and developing CCA globally. The northeast of Thailand (Isan) is the world’s hot spot of liver fluke infection and CCA. Early detection, diagnosis, and surgical intervention/curative treatment of CCA are critical to increase life expectancy and quality of life of people in the region and globally. Despite concentrated recent efforts focusing on a multidisciplinary approach to understand the ecology, epidemiology, biology, public health, and socialsignificance of infection by cancer causing liver flukes, it remains an underestimated and under-resourced public health problem. In addition, it is still believed to be a regional problem without global significance—this is not the case. This book focuses on O. viverrini as the main causative agent of CCA in Southeast Asia, but many aspects detailed in the following chapters also relate to the two other liver fluke species. Our aim is to produce a holistic framework including the basic biology of O. viverrini and its relation to the epidemiology of the disease through diagnosis to treatment, including palliative methods,pathology, and control.
AU  - Khuntikeo,N
AU  - Andrews,RH
AU  - Petney,TN
AU  - Khan,SA
DO  - 10.1007/978-3-031-35166-2_1
EP  - 5
PY  - 2023///
SP  - 1
TI  - Introduction
T1  - Recent Results in Cancer Research
UR  - http://dx.doi.org/10.1007/978-3-031-35166-2_1
ER  -
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