Imperial College London

ProfessorSianHarding

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiac Pharmacology
 
 
 
//

Contact

 

+44 (0)20 7594 3009sian.harding Website

 
 
//

Location

 

435ICTEM buildingHammersmith Campus

//

Summary

 

Summary

Sian Harding is Professor of Cardiac Pharmacology at the National Heart and Lung Institute, Imperial College London, and a co-investigator within the UKRMP Immunomodulation Hub.

She obtained her Ph.D. in Pharmacology from King's College, London in 1981, and since then the primary focus of her work has been cardiomyocyte function in the failing heart. This has extended to gene therapy to modulate cardiomyocyte function, and she is Scientific PI for the UK's first clinical trial on myocardial gene therapy. More recently the scope has extended to the characterisation of cardiomyocytes derived from embryonic stem cells, and their use in cardiac repair, tissue engineering and drug discovery.

Professor Harding is Past-President of the European Section of the International Society for Heart Research and Fellow of the AHA, ESC and ISHR. She sits on the Nuffield Council on Bioethics and the Scientific Advisory Board of the PPP "Stem Cells for Safer Medicines".

Professor Harding delivered her Inaugural Lecture, entitled 'Reviving the Failing Heart: one cell at a time', on 3 April 2007.  The abstract and other details of the lecture can be found here.

 

 

YouTube placeholder

Publications

Journals

Constantinou C, Miranda Almeida A, Chaves Guerrero P, et al., Human pluripotent stem cell-derived cardiomyocytes as a targetplatform for paracrine protection by cardiac mesenchymal stromalcells, Scientific Reports, ISSN:2045-2322

Pitoulis FG, Hasan W, Papadaki M, et al., 2020, Intact myocardial preparations reveal intrinsic transmural heterogeneity in cardiac mechanics, Journal of Molecular and Cellular Cardiology, Vol:141, ISSN:0022-2828, Pages:11-16

Schobesberger S, Wright PT, Poulet C, et al., 2020, beta(3)-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes, Elife, Vol:9, ISSN:2050-084X, Pages:1-15

Fiedler LR, Chapman K, Xie M, et al., 2020, MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo (vol 24, 579.e1,2019), Cell Stem Cell, Vol:26, ISSN:1934-5909, Pages:458-458

Sparks H, Dvinskikh L, Firth J, et al., Development a flexible light-sheet fluorescence microscope for high-speed 3D imaging of calcium dynamics and 3D imaging of cellular microstructure, Journal of Biophotonics, ISSN:1864-063X

More Publications