Sian Harding is Professor of Cardiac Pharmacology at the National Heart and Lung Institute, Imperial College, as well as Institute Lead for Women for Athena Swan, and a co-investigator within the UKRMP Immunomodulation Hub.
She obtained her Ph.D. in Pharmacology from King's College, London in 1981, and since then the primary focus of her work has been cardiomyocyte function in the failing heart. This has extended to gene therapy to modulate cardiomyocyte function, and she is Scientific PI for the UK's first clinical trial on myocardial gene therapy. More recently the scope has extended to the characterisation of cardiomyocytes derived from embryonic stem cells, and their use in cardiac repair, tissue engineering and drug discovery.
Professor Harding is Past-President of the European Section of the International Society for Heart Research and Fellow of the AHA, ESC and ISHR. She sits on the Nuffield Council on Bioethics and the Scientific Advisory Board of the PPP "Stem Cells for Safer Medicines".
Professor Harding delivered her Inaugural Lecture, entitled 'Reviving the Failing Heart: one cell at a time', on 3 April 2007. The abstract and other details of the lecture can be found here.
et al., The adaptive immune response to cardiac injury - the true roadblock to effective regenerative therapies?, Npjregenmed
et al., 2017, Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease, Disease Models & Mechanisms, Vol:10, ISSN:1754-8403, Pages:259-270
et al., 2017, Quantifying the Release of Biomarkers of Myocardial Necrosis from Cardiac Myocytes and Intact Myocardium., Clin Chem, Vol:63, Pages:990-996
et al., 2016, Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering., J Tissue Eng Regen Med
et al., 2016, Doxorubicin modulates the real-time oxygen consumption rate of freshly isolated adult rat and human ventricular cardiomyocytes, Frontiers in CardioVascular Biology Meeting (FCVB), OXFORD UNIV PRESS, Pages:S111-S111, ISSN:0008-6363