Imperial College London

ProfessorSianHarding

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiac Pharmacology
 
 
 
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Contact

 

+44 (0)20 7594 3009sian.harding Website

 
 
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Location

 

435ICTEM buildingHammersmith Campus

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Summary

 

Summary

Sian Harding is Professor of Cardiac Pharmacology at the National Heart and Lung Institute, Imperial College, as well as Institute Lead for Women for Athena Swan, and a co-investigator within the UKRMP Immunomodulation Hub.

She obtained her Ph.D. in Pharmacology from King's College, London in 1981, and since then the primary focus of her work has been cardiomyocyte function in the failing heart. This has extended to gene therapy to modulate cardiomyocyte function, and she is Scientific PI for the UK's first clinical trial on myocardial gene therapy. More recently the scope has extended to the characterisation of cardiomyocytes derived from embryonic stem cells, and their use in cardiac repair, tissue engineering and drug discovery.

Professor Harding is Past-President of the European Section of the International Society for Heart Research and Fellow of the AHA, ESC and ISHR. She sits on the Nuffield Council on Bioethics and the Scientific Advisory Board of the PPP "Stem Cells for Safer Medicines".

Professor Harding delivered her Inaugural Lecture, entitled 'Reviving the Failing Heart: one cell at a time', on 3 April 2007.  The abstract and other details of the lecture can be found here.

 

 

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Publications

Journals

Sattler S, Fairchild P, Watt F, et al., The adaptive immune response to cardiac injury - the true roadblock to effective regenerative therapies?, Npjregenmed

Hasham MG, Baxan N, Stuckey DJ, et al., 2017, Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease, Disease Models & Mechanisms, Vol:10, ISSN:1754-8403, Pages:259-270

Marjot J, Kaier TE, Martin ED, et al., 2017, Quantifying the Release of Biomarkers of Myocardial Necrosis from Cardiac Myocytes and Intact Myocardium., Clin Chem, Vol:63, Pages:990-996

Bagdadi AV, Safari M, Dubey P, et al., 2016, Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering., J Tissue Eng Regen Med

Conference

Elder JM, O'Gara P, Sanchez-Alonso JL, et al., 2016, Doxorubicin modulates the real-time oxygen consumption rate of freshly isolated adult rat and human ventricular cardiomyocytes, Frontiers in CardioVascular Biology Meeting (FCVB), OXFORD UNIV PRESS, Pages:S111-S111, ISSN:0008-6363

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