Sian Harding is Professor of Cardiac Pharmacology at the National Heart and Lung Institute, Imperial College, as well as Institute Lead for Women for Athena Swan, and a co-investigator within the UKRMP Immunomodulation Hub.
She obtained her Ph.D. in Pharmacology from King's College, London in 1981, and since then the primary focus of her work has been cardiomyocyte function in the failing heart. This has extended to gene therapy to modulate cardiomyocyte function, and she is Scientific PI for the UK's first clinical trial on myocardial gene therapy. More recently the scope has extended to the characterisation of cardiomyocytes derived from embryonic stem cells, and their use in cardiac repair, tissue engineering and drug discovery.
Professor Harding is Past-President of the European Section of the International Society for Heart Research and Fellow of the AHA, ESC and ISHR. She sits on the Nuffield Council on Bioethics and the Scientific Advisory Board of the PPP "Stem Cells for Safer Medicines".
Professor Harding delivered her Inaugural Lecture, entitled 'Reviving the Failing Heart: one cell at a time', on 3 April 2007. The abstract and other details of the lecture can be found here.
et al., 2016, High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes, Journal of Biophotonics, Vol:9, ISSN:1864-063X, Pages:311-323
et al., 2016, Concise Review: Pluripotent Stem Cell-Derived Cardiac Cells, A Promising Cell Source for Therapy of Heart Failure: Where Do We Stand?, Stem Cells, Vol:34, ISSN:1066-5099, Pages:34-43
et al., 2016, Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy, Cardiovascular Research, Vol:110, ISSN:0008-6363, Pages:238-248
et al., 2015, Signaling Via PI3K/FOXO1A Pathway Modulates Formation and Survival of Human Embryonic Stem Cell-Derived Endothelial Cells, Stem Cells and Development, Vol:24, ISSN:1547-3287, Pages:869-878
et al., 2015, Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts, Cardiovascular Research, Vol:105, ISSN:0008-6363, Pages:31-43