Imperial College London

ProfessorSianHarding

Faculty of MedicineNational Heart & Lung Institute

Interim Head of NHLI, Professor of Cardiac Pharmacology
 
 
 
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Contact

 

+44 (0)20 7594 3009sian.harding Website

 
 
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Location

 

435ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

367 results found

Adamowicz M, Morgan CC, Haubner BJ, Noseda M, Collins MJ, Paiva MA, Srivastava PK, Gellert P, Razzaghi B, O'Gara P, Raina P, Game L, Bottolo L, Schneider MD, Harding SE, Penninger J, Aitman TJet al., 2018, Functionally Conserved Noncoding Regulators of Cardiomyocyte Proliferation and Regeneration in Mouse and Human, CIRCULATION-CARDIOVASCULAR GENETICS, Vol: 11, ISSN: 1942-325X

JOURNAL ARTICLE

Bagdadi AV, Safari M, Dubey P, Basnett P, Sofokleous P, Humphrey E, Locke I, Edirisinghe M, Terracciano C, Boccaccini AR, Knowles JC, Harding SE, Roy Iet al., 2018, Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol: 12, Pages: E495-E512, ISSN: 1932-6254

JOURNAL ARTICLE

Couch LS, Harding SE, 2018, Takotsubo Syndrome: Stress or NO Stress?, JACC Basic Transl Sci, Vol: 3, Pages: 227-229

JOURNAL ARTICLE

Foldes G, Lawlor K, Harding SE, Randi AMet al., 2018, STAT3 mediates differentiation and maintenance of human pluripotent stem-derived endothelial cells, 5th Congress of the ESC-Council-on-Basic-Cardiovascular-Science on Frontiers in Cardio Vascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S39-S39, ISSN: 0008-6363

CONFERENCE PAPER

Hou H, Zhao Z, Machuki JO, Zhang L, Zhang Y, Fu L, Wu J, Liu Y, Harding SE, Sun Het al., 2018, Estrogen deficiency compromised the beta(2)AR-Gs/Gi coupling: implications for arrhythmia and cardiac injury, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Vol: 470, Pages: 559-570, ISSN: 0031-6768

JOURNAL ARTICLE

Husveth-Toth M, Gara E, Nemes A, Molnar AA, Csepi K, Radovits T, Harding SE, Merkely B, Foldes Get al., 2018, Human pluripotent stem cell-derived endothelial cells are vasoactive in vitro and capable of engineering 3D vascular grafts, 5th Congress of the ESC-Council-on-Basic-Cardiovascular-Science on Frontiers in Cardio Vascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S111-S111, ISSN: 0008-6363

CONFERENCE PAPER

Kapnisi M, Mansfield C, Marijon C, Guex AG, Perbellini F, Bardi I, Humphrey EJ, Puetzer JL, Mawad D, Koutsogeorgis DC, Stuckey DJ, Terracciano CM, Harding SE, Stevens MMet al., 2018, Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction, ADVANCED FUNCTIONAL MATERIALS, Vol: 28, ISSN: 1616-301X

JOURNAL ARTICLE

Leong KMW, Ng FS, Roney C, Cantwell C, Shun-Shin MJ, Linton NWF, Whinnett ZI, Lefroy DC, Davies DW, Harding SE, Lim PB, Francis D, Peters NS, Varnava AM, Kanagaratnam Pet al., 2018, Repolarization abnormalities unmasked with exercise in sudden cardiac death survivors with structurally normal hearts, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 29, Pages: 115-126, ISSN: 1045-3873

JOURNAL ARTICLE

Panahi M, Papanikolaou A, Torabi A, Zhang J-G, Khan H, Vazir A, Hasham MG, Cleland JGF, Rosenthal NA, Harding SE, Sattler Set al., 2018, Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition., Cardiovasc Res, Vol: 114, Pages: 1445-1461

Following a myocardial infarction (MI), the immune system helps to repair ischaemic damage and restore tissue integrity, but excessive inflammation has been implicated in adverse cardiac remodelling and development towards heart failure (HF). Pre-clinical studies suggest that timely resolution of inflammation may help prevent HF development and progression. Therapeutic attempts to prevent excessive post-MI inflammation in patients have included pharmacological interventions ranging from broad immunosuppression to immunomodulatory approaches targeting specific cell types or factors with the aim to maintain beneficial aspects of the early post-MI immune response. These include the blockade of early initiators of inflammation including reactive oxygen species and complement, inhibition of mast cell degranulation and leucocyte infiltration, blockade of inflammatory cytokines, and inhibition of adaptive B and T-lymphocytes. Herein, we provide a systematic review on post-MI immunomodulation trials and a meta-analysis of studies targeting the inflammatory cytokine Interleukin-1. Despite an enormous effort into a significant number of clinical trials on a variety of targets, a striking heterogeneity in study population, timing and type of treatment, and highly variable endpoints limits the possibility for meaningful meta-analyses. To conclude, we highlight critical considerations for future studies including (i) the therapeutic window of opportunity, (ii) immunological effects of routine post-MI medication, (iii) stratification of the highly diverse post-MI patient population, (iv) the potential benefits of combining immunomodulatory with regenerative therapies, and at last (v) the potential side effects of immunotherapies.

JOURNAL ARTICLE

Perbellini F, Watson SA, Scigliano M, Alayoubi S, Tkach S, Bardi I, Quaife N, Kane C, Dufton NP, Simon A, Sikkel MB, Faggian G, Randi AM, Gorelik J, Harding SE, Terracciano CMet al., 2018, Investigation of cardiac fibroblasts using myocardial slices, CARDIOVASCULAR RESEARCH, Vol: 114, Pages: 77-89, ISSN: 0008-6363

JOURNAL ARTICLE

Ricardo CP, Hellen N, Foldes G, Kodagoda T, Terracciano CM, Duchen MR, Harding SEet al., 2018, LOW LEVELS OF THE A3243G MTDNA MUTATION IN HUMAN INDUCED PLURIPOTENT STEM CELLCARDIOMYOCYTES DO NOT CAUSE FUNCTIONAL OR METABOLIC DISTURBANCES BUT INCREASE WITH FURTHER PASSAGING, Autumn Meeting of the British-Society-for-Cardiovascular-Research on Cardiac Metabolic Disorders and Mitochondrial Dysfunction, Publisher: BMJ PUBLISHING GROUP, Pages: A8-A9, ISSN: 1355-6037

CONFERENCE PAPER

Wright PT, Bhogal NK, Diakonov I, Pannell LMK, Perera RK, Bork NI, Schobesberger S, Lucarelli C, Faggian G, Alvarez-Laviada A, Zaccolo M, Kamp TJ, Balijepalli RC, Lyon AR, Harding SE, Nikolaev VO, Gorelik Jet al., 2018, Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in beta(2)AR-cAMP Responsiveness in Murine Hearts, CELL REPORTS, Vol: 23, Pages: 459-469, ISSN: 2211-1247

JOURNAL ARTICLE

Cappelletti S, Ciallella C, Aromatario M, Ashrafian H, Harding S, Athanasiou Tet al., 2017, Takotsubo Cardiomyopathy and Sepsis: A Systematic Review, ANGIOLOGY, Vol: 68, Pages: 288-303, ISSN: 0003-3197

JOURNAL ARTICLE

Chow A, Stuckey DJ, Kidher E, Rocco M, Jabbour RJ, Mansfield CA, Darzi A, Harding SE, Stevens MM, Athanasiou Tet al., 2017, Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Encapsulating Bioactive Hydrogels Improve Rat Heart Function Post Myocardial Infarction, STEM CELL REPORTS, Vol: 9, Pages: 1415-1422, ISSN: 2213-6711

JOURNAL ARTICLE

Foldes G, Gara E, Husveth-Toth M, Nemes A, Merkely B, Harding SEet al., 2017, 3D culture conditioning modulates arterial specification of human pluripotent stem cells-derived endothelial cells, 2nd Joint Meeting of the European-Society-for-Microcirculation (ESM) and European-Vascular-Biology-Organisation (EVBO), Publisher: KARGER, Pages: 12-13, ISSN: 1018-1172

CONFERENCE PAPER

Guex AG, Spicer CD, Armgarth A, Gelmi A, Humphrey EJ, Terracciano CM, Harding SE, Stevens MMet al., 2017, Electrospun aniline-tetramer-co-polycaprolactone fibers for conductive, biodegradable scaffolds, MRS COMMUNICATIONS, Vol: 7, Pages: 375-382, ISSN: 2159-6859

JOURNAL ARTICLE

Hasham MG, Baxan N, Stuckey DJ, Branca J, Perkins B, Dent O, Duffy T, Hameed TS, Stella SE, Bellahcene M, Schneider MD, Harding SE, Rosenthal N, Sattler Set al., 2017, Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease, DISEASE MODELS & MECHANISMS, Vol: 10, Pages: 259-270, ISSN: 1754-8403

JOURNAL ARTICLE

Leong KMW, Ng FS, Yao C, Roney C, Taraborrelli P, Linton NWF, Whinnett ZI, Lefroy DC, Davies DW, Lim PB, Harding SE, Peters NS, Kanagaratnam P, Varnava AMet al., 2017, ST-Elevation Magnitude Correlates With Right Ventricular Outflow Tract Conduction Delay in Type I Brugada ECG, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, Vol: 10, ISSN: 1941-3149

JOURNAL ARTICLE

Marjot J, Kaier TE, Martin ED, Reji SS, Copeland O, Iqbal M, Goodson B, Hamren S, Harding SE, Marber MSet al., 2017, Quantifying the Release of Biomarkers of Myocardial Necrosis from Cardiac Myocytes and Intact Myocardium, CLINICAL CHEMISTRY, Vol: 63, Pages: 990-996, ISSN: 0009-9147

JOURNAL ARTICLE

Martinez VG, Ontoria-Oviedo I, Ricardo CP, Harding SE, Sacedon R, Varas A, Zapata A, Sepulveda P, Vicente Aet al., 2017, Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells, STEM CELL RESEARCH & THERAPY, Vol: 8, ISSN: 1757-6512

JOURNAL ARTICLE

Perbellini F, Bardi I, Watson S, Scigliano M, Alayoubi S, Harding SE, Terracciano CMet al., 2017, Cell therapy of the heart studied using adult myocardial slices in vitro, Annual Conference of the British-Society-for-Gene-and-Cell-Therapy / Joint UK-Regenerative-Medicine-Platform Meeting, Publisher: MARY ANN LIEBERT, INC, Pages: A19-A20, ISSN: 1043-0342

CONFERENCE PAPER

Sattler S, Fairchild P, Watt FM, Rosenthal N, Harding SEet al., 2017, The adaptive immune response to cardiac injury-the true roadblock to effective regenerative therapies?, NPJ REGENERATIVE MEDICINE, Vol: 2, ISSN: 2057-3995

JOURNAL ARTICLE

Schobesberger S, Wright P, Tokar S, Bhargava A, Mansfield C, Glukhov AV, Poulet C, Buzuk A, Monszpart A, Sikkel M, Harding SE, Nikolaev VO, Lyon AR, Gorelik Jet al., 2017, T-tubule remodelling disturbs localized beta(2)-adrenergic signalling in rat ventricular myocytes during the progression of heart failure, CARDIOVASCULAR RESEARCH, Vol: 113, Pages: 770-782, ISSN: 0008-6363

JOURNAL ARTICLE

Sikkel MB, Francis DP, Howard J, Gordon F, Rowlands C, Peters NS, Lyon AR, Harding SE, MacLeod KTet al., 2017, Hierarchical statistical techniques are necessary to draw reliable conclusions from analysis of isolated cardiomyocyte studies, CARDIOVASCULAR RESEARCH, Vol: 113, Pages: 1743-1752, ISSN: 0008-6363

JOURNAL ARTICLE

Sikkel MB, Kumar S, Maioli V, Rowlands C, Gordon F, Harding SE, Lyon AR, MacLeod KT, Dunsby Cet al., 2017, Erratum: High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes: [J. Biophotonics 9, No. 3, 311-323 (2016)]., J Biophotonics, Vol: 10, Pages: 744-745

In the article by M.B. Sikkel et al. (doi: 10.1002/jbio.201500193), published in J. Biophotonics 9, 311-323 (2016), an error occurred in the computer code that was used to generate Figure 3. This erratum is published to correct Figure 3, the calculated value of tgeom and the experimentally determined value of toptics in the text of the article.

JOURNAL ARTICLE

Yang C, Xu Y, Yu M, Lee D, Alharti S, Hellen N, Shaik NA, Banaganapalli B, Mohamoud HSA, Elango R, Przyborski S, Tenin G, Williams S, O'Sullivan J, Al-Radi OO, Atta J, Harding SE, Keavney B, Lako M, Armstrong Let al., 2017, Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis, HUMAN MOLECULAR GENETICS, Vol: 26, Pages: 3031-3045, ISSN: 0964-6906

JOURNAL ARTICLE

Athanasiou T, Patel V, Garas G, Ashrafian H, Hull L, Sevdalis N, Harding S, Darzi A, Paroutis Set al., 2016, Mentoring perception, scientific collaboration and research performance: is there a "gender gap' in academic medicine? An Academic Health Science Centre perspective, POSTGRADUATE MEDICAL JOURNAL, Vol: 92, Pages: 581-586, ISSN: 0032-5473

JOURNAL ARTICLE

Elder JM, O'Gara P, Sanchez-Alonso JL, Harding SE, Lyon ARet al., 2016, Doxorubicin modulates the real-time oxygen consumption rate of freshly isolated adult rat and human ventricular cardiomyocytes, Frontiers in CardioVascular Biology Meeting (FCVB), Publisher: OXFORD UNIV PRESS, Pages: S111-S111, ISSN: 0008-6363

CONFERENCE PAPER

Foldes G, Hellen N, Vittay O, Harding SEet al., 2016, Hippo signalling modulates survival of human induced pluripotent stem cell-derived cardiomyocytes, Frontiers in CardioVascular Biology Meeting (FCVB), Publisher: OXFORD UNIV PRESS, Pages: S92-S93, ISSN: 0008-6363

CONFERENCE PAPER

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