Imperial College London
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ProfessorSianHarding

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Cardiac Pharmacology
 
 
 
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Contact

 

+44 (0)20 7594 3009sian.harding Website

 
 
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Location

 

435ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Owen:2019:10.1007/s10974-019-09528-8,
author = {Owen, TJ and Harding, SE},
doi = {10.1007/s10974-019-09528-8},
journal = {Journal of Muscle Research and Cell Motility},
pages = {151--157},
title = {Multi-cellularity in cardiac tissue engineering, how close are we to native heart tissue?},
url = {http://dx.doi.org/10.1007/s10974-019-09528-8},
volume = {40},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Tissue engineering is a complex field where the elements of biology and engineering are combined in an attempt to recapitulate the native environment of the body. Tissue engineering has shown one thing categorically; that the human body is extremely complex and it is truly a difficult task to generate this in the lab. There have been varied attempts at trying to generate a model for the heart with numerous cell types and different scaffolds or materials. The common underlying theme in these approaches is to combine together matrix material and different cell types to make something similar to heart tissue. Multi-cellularity is an essential aspect of the heart and therefore critical to any approach which would try to mimic such a complex tissue. The heart is made up of many cell types that combine to form complex structures like: deformable chambers, a tri-layered heart muscle, and vessels. Thus, in this review we will summarise how tissue engineering has progressed in modelling the heart and what gaps still exist in this dynamic field.
AU  - Owen,TJ
AU  - Harding,SE
DO  - 10.1007/s10974-019-09528-8
EP  - 157
PY  - 2019///
SN  - 0142-4319
SP  - 151
TI  - Multi-cellularity in cardiac tissue engineering, how close are we to native heart tissue?
T2  - Journal of Muscle Research and Cell Motility
UR  - http://dx.doi.org/10.1007/s10974-019-09528-8
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000484545700009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007%2Fs10974-019-09528-8
UR  - http://hdl.handle.net/10044/1/73773
VL  - 40
ER  -
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