Imperial College London

ProfessorSimakAli

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Molecular Endocrine Oncology
 
 
 
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Contact

 

+44 (0)20 7594 2811simak.ali

 
 
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Location

 

133ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

153 results found

Clark AJ, Ali S, Archibald AL, Bessos H, Brown P, Harris S, McClenaghan M, Prowse C, Simons JP, Whitelaw CBet al., 1989, The molecular manipulation of milk composition., Genome, Vol: 31, Pages: 950-955, ISSN: 0831-2796

The introduction of cloned genes into the mouse germ line is now routine. Although more difficult technically, gene transfer has been accomplished in farm animals and offers the potential for genetic improvement. In this regard, we have been investigating the use of transgenic animals as production vehicles for high value proteins in milk. We have shown that DNA sequences derived from the gene encoding sheep beta-lactoglobulin mediate efficient and specific expression in the mammary gland. A fusion gene comprising beta-lactoglobulin sequences and those encoding antihemophilic human factor IX has been constructed. This construct has been introduced into sheep; it is expressed in the mammary gland, and the corresponding protein is secreted into milk.

Journal article

Harris S, Ali S, Anderson S, Archibald AL, Clark AJet al., 1988, Complete nucleotide sequence of the genomic ovine beta-lactoglobulin gene., Nucleic Acids Res, Vol: 16, Pages: 10379-10380, ISSN: 0305-1048

Journal article

ALI S, CLARK AJ, 1988, CHARACTERIZATION OF THE GENE ENCODING OVINE BETA-LACTOGLOBULIN - SIMILARITY TO THE GENES FOR RETINOL BINDING-PROTEIN AND OTHER SECRETORY PROTEINS, JOURNAL OF MOLECULAR BIOLOGY, Vol: 199, Pages: 415-426, ISSN: 0022-2836

Journal article

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