Imperial College London

ProfessorSimakAli

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Molecular Endocrine Oncology
 
 
 
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Contact

 

+44 (0)20 7594 2811simak.ali

 
 
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Location

 

133ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hindley:2018:10.1038/s41467-018-03491-7,
author = {Hindley, JW and Elani, Y and McGilvery, CM and Ali, S and Bevan, CL and Law, R and Ces, O},
doi = {10.1038/s41467-018-03491-7},
journal = {Nature Communications},
title = {Light-triggered enzymatic reactions in nested vesicle reactors},
url = {http://dx.doi.org/10.1038/s41467-018-03491-7},
volume = {9},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Cell-sized vesicles have tremendous potential both as miniaturised pL reaction vessels and in bottom-up synthetic biology as chassis for artificial cells. In both these areas the introduction of light-responsive modules affords increased functionality, for example, to initiate enzymatic reactions in the vesicle interior with spatiotemporal control. Here we report a system composed of nested vesicles where the inner compartments act as phototransducers, responding to ultraviolet irradiation through diacetylene polymerisation-induced pore formation to initiate enzymatic reactions. The controlled release and hydrolysis of a fluorogenic β-galactosidase substrate in the external compartment is demonstrated, where the rate of reaction can be modulated by varying ultraviolet exposure time. Such cell-like nested microreactor structures could be utilised in fields from biocatalysis through to drug delivery.
AU - Hindley,JW
AU - Elani,Y
AU - McGilvery,CM
AU - Ali,S
AU - Bevan,CL
AU - Law,R
AU - Ces,O
DO - 10.1038/s41467-018-03491-7
PY - 2018///
SN - 2041-1723
TI - Light-triggered enzymatic reactions in nested vesicle reactors
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/s41467-018-03491-7
UR - http://hdl.handle.net/10044/1/56705
VL - 9
ER -