Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Professor of Molecular Endocrine Oncology



+44 (0)20 7594 2811simak.ali




133ICTEM buildingHammersmith Campus






BibTex format

author = {Hindley, JW and Elani, Y and McGilvery, CM and Ali, S and Bevan, CL and Law, R and Ces, O},
doi = {10.1038/s41467-018-03491-7},
journal = {Nature Communications},
title = {Light-triggered enzymatic reactions in nested vesicle reactors},
url = {},
volume = {9},
year = {2018}

RIS format (EndNote, RefMan)

AB - Cell-sized vesicles have tremendous potential both as miniaturised pL reaction vessels and in bottom-up synthetic biology as chassis for artificial cells. In both these areas the introduction of light-responsive modules affords increased functionality, for example, to initiate enzymatic reactions in the vesicle interior with spatiotemporal control. Here we report a system composed of nested vesicles where the inner compartments act as phototransducers, responding to ultraviolet irradiation through diacetylene polymerisation-induced pore formation to initiate enzymatic reactions. The controlled release and hydrolysis of a fluorogenic β-galactosidase substrate in the external compartment is demonstrated, where the rate of reaction can be modulated by varying ultraviolet exposure time. Such cell-like nested microreactor structures could be utilised in fields from biocatalysis through to drug delivery.
AU - Hindley,JW
AU - Elani,Y
AU - McGilvery,CM
AU - Ali,S
AU - Bevan,CL
AU - Law,R
AU - Ces,O
DO - 10.1038/s41467-018-03491-7
PY - 2018///
SN - 2041-1723
TI - Light-triggered enzymatic reactions in nested vesicle reactors
T2 - Nature Communications
UR -
UR -
VL - 9
ER -